Once daily versus twice-daily radiotherapy in the management of limited disease small cell lung cancer - Decision criteria in routine practise

被引：16

作者：

Glatzer, Markus ^{[1
]}

Faivre-Finn, Corinne ^{[2
,3
]}

De Ruysscher, Dirk ^{[4
]}

Widder, Joachim ^{[5
]}

Van Houtte, Paul ^{[6
]}

Troost, Esther G. C. ^{[7
,8
,9
,10
,11
,12
]}

Dahele, M. R. ^{[13
]}

Slotman, Ben J. ^{[13
]}

Ramella, Sara ^{[14
]}

Poettgen, Christoph ^{[15
]}

Peeters, Stephanie T. H. ^{[4
]}

Nestle, Ursula ^{[16
,17
]}

McDonald, Fiona ^{[18
]}

Le Pechoux, Cecile ^{[19
]}

Dziadziuszko, Rafal ^{[20
]}

Belderbos, Jose ^{[21
]}

Putora, Paul M. ^{[1
,22
]}

机构：

[1] Kantonsspital St Gallen, Dept Radiat Oncol, CH-9007 St Gallen, Switzerland

[2] Univ Manchester, Div Canc Sci, Manchester, Lancs, England

[3] Christie NHS Fdn Trust Manchester, Manchester, Lancs, England

[4] Maastricht Univ, Med Ctr, Dept Radiat Oncol, Maastro Clin,Sch Oncol & Dev Biol GROW, Maastricht, Netherlands

[5] Med Univ Vienna, Ctr Comprehens Canc, Dept Radiat Oncol, Vienna, Austria

[6] Univ Libre Bruxelles, Inst Bordet, Dept Radiat Oncol, Brussels, Belgium

[7] OncoRay Natl Ctr Radiat Res Oncol, Dresden, Germany

[8] Fac Med, Dept Radiotherapy & Radiat Oncol, Dresden, Germany

[9] Univ Hosp Carl Gustav Carus Dresden, Dresden, Germany

[10] Helmholtz Zentrum Dresden Rossendorf, Inst Radiooncol OncoRay, Dresden, Germany

[11] German Canc Consortium DKTK, Partner Site Dresden, Dresden, Germany

[12] German Canc Res Ctr, Heidelberg, Germany

[13] Amsterdam Univ Med Ctr, VUMC, Dept Radiat Oncol, Amsterdam, Netherlands

[14] Campus Biomed Univ, Dept Radiat Oncol, Rome, Italy

[15] Univ Duisburg Essen, West German Tumor Ctr, Dept Radiat Oncol, Med Sch, Duisburg, Germany

[16] Kliniken Maria Hilf, Dept Radiat Oncol, Monchengladbach, Germany

[17] Univ Hosp Freiburg, Dept Radiat Oncol, Freiburg, Germany

[18] Royal Marsden NHS Fdn Trust, Dept Radiotherapy, London, England

[19] Gustave Roussy, Dept Radiat Oncol, Paris, France

[20] Dept Radiotherapy & Oncol, Gdansk, Poland

[21] Netherlands Canc Inst, Dept Radiat Oncol, Amsterdam, Netherlands

[22] Univ Bern, Dept Radiat Oncol, Bern, Switzerland

来源：

RADIOTHERAPY AND ONCOLOGY | 2020年 / 150卷

关键词：

SCLC; Limited disease small cell lung cancer; Decision making; BID radiotherapy; QD radiotherapy;

D O I：

10.1016/j.radonc.2020.05.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: In limited disease small cell lung cancer (LD-SCLC), the CONVERT trial has not demonstrated superiority of once-daily (QD) radiotherapy (66 Gy) over twice-daily (BID) radiotherapy (45 Gy). We explored the factors influencing the selection between QD and BID regimens. Methods: Thirteen experienced European thoracic radiation oncologists as selected by the European Society for Therapeutic Radiation Oncology (ESTRO) were asked to describe their strategies in the management of LD-SCLC. Treatment strategies were subsequently converted into decision trees and analysed for agreement and discrepancies. Results: Logistic reasons, patients' performance status and radiotherapy dose constraints were the three major decision criteria used by most experts in decision making. The use of QD and BID regimens was balanced among European experts, but there was a trend towards the BID regimen for fit patients able to travel twice a day to the radiotherapy site. Conclusion: BID and QD radiotherapy are both accepted regimens among experts and the decision is influenced by pragmatic factors such as availability of transportation. (C) 2020 Elsevier B.V. All rights reserved. Radiotherapy and Oncology 150 (2020) 26-29

引用

页码：26 / 29

页数：4

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