Preparation of therapeutic-laden konjac hydrogel for tumor combination therapy

被引：55
作者：
Liu, Yiyun [1 ]
Xi, Yixin [1 ]
Zhao, Jiulong [2 ]
Zhao, Jiayan [1 ]
Li, Jincan [1 ]
Huang, Guoqi [1 ]
Li, Junqiang [1 ]
Fang, Fei [1 ]
Gu, Lingling [1 ]
Wang, Shige [1 ]
机构：
[1] Univ Shanghai Sci & Technol, Coll Sci, 334 Jungong Rd, Shanghai 200093, Peoples R China
[2] Second Mil Med Univ, Changhai Hosp, Dept Gastroenterol, 168 Changhai Rd, Shanghai 200433, Peoples R China
来源：
CHEMICAL ENGINEERING JOURNAL | 2019年 / 375卷
基金：
中国国家自然科学基金;
关键词：
Konjac hydrogel; Polydopamine; Tumor therapy; 5-FU; Photothermal; DRUG-DELIVERY; PHOTOTHERMAL CONVERSION; NANOPARTICLES; EFFICIENT; NANOCOMPOSITE; CHEMOTHERAPY; NANOSPHERES; REGRESSION; NANOSHEETS; AGENT;
D O I：
10.1016/j.cej.2019.122048
中图分类号：
X [环境科学、安全科学];
学科分类号：
08 ; 0830 ;
摘要：
Featured with three-dimensional network structure, polymer hydrogels have found tremendous applications in biomedical fields. In this study, therapeutic-laden Konjac glucomannan (KGM) hydrogel was prepared by injecting polydopamine (PDA)/5-fluorouracil (5-FU)/calcium folinate (CF)/KGM alkaline solution to the target area, for the synergistic tumor photothermal and chemotherapy. In alkaline solution, dopamine can be synchronously polymerized to form PDA, while KGM can be hydrolyzed and transformed into a thermally irreversible KGM hydrogel. Besides, the alkaline condition can increase the solubility of 5-FU. The hydrogel matrix can control the release of 5-FU and CF. PDA renders the composite hydrogel excellent tumor photothermal therapy ability. Moreover, CF can be used as a synergist to enhance the tumor chemotherapy efficiency of 5-FU. With convenient handling, excellent photothermal conversion ability and high biocompatibility, the multifunctional hydrogel system is anticipated to find a promising translational potential in clinical therapeutic applications.
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页数：11
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