Intravenous Mineralocorticoid Receptor Antagonist Use in Acutely Decompensated Heart Failure with Diuretic Resistance

被引：3
作者：
Girerd, Nicolas [1 ,2 ]
Aubry, Matthieu [3 ,4 ]
Lantelme, Pierre [3 ,4 ,5 ]
Huttin, Olivier [1 ,2 ]
Rossignol, Patrick [1 ,2 ]
机构：
[1] Univ Lorraine, Ctr Invest Clin 1433, Inserm 1116, CHRU Nancy, Nancy, France
[2] Univ Lorraine, INI CRCT Cardiovasc & Renal Clin Trialists F CRIN, Nancy, France
[3] Hop Croix Rousse, European Soc Hypertens, Dept Cardiol, Excellence Ctr, Lyon, France
[4] Hosp Civils Lyon, Hop Lyon Sud, Lyon, France
[5] Univ Claude Bernard Lyon 1, Univ Lyon, INSA Lyon, CREATIS,CNRS,UMR5220,INSERM,U1044, Lyon, France
来源：
INTERNATIONAL HEART JOURNAL | 2021年 / 62卷 / 01期
关键词：
Congestive heart failure; Furosemide; Dyspnea; Cardiac edema; Cardiovascular diseases; Potassium canrenoate;
D O I：
10.1536/ihj.20-442
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Intravenous mineralocorticoid receptor antagonists (MRAs) have been used in some centers for decades to reduce the risk of hypokalemia and boost diuresis in acutely decompensated heart failure (ADHF). We report the well-tolerated use of intravenous MRAs as a rescue procedure in 3 patients admitted for ADHF with important diuretic resistance. Undertaking trials evaluating the effect of this therapeutic strategy in ADHF could represent a promising avenue.
引用
收藏
页码：193 / 196
页数：4
相关论文
共 9 条
[1]   Efficacy and Safety of Spironolactone in Acute Heart Failure The ATHENA-HF Randomized Clinical Trial [J].
Butler, Javed ;
Anstrom, Kevin J. ;
Felker, G. Michael ;
Givertz, Michael M. ;
Kalogeropoulos, Andreas P. ;
Konstam, Marvin A. ;
Mann, Douglas L. ;
Margulies, Kenneth B. ;
McNulty, Steven E. ;
Mentz, Robert J. ;
Redfield, Margaret M. ;
Tang, W. H. Wilson ;
Whellan, David J. ;
Shah, Monica ;
Desvigne-Nickens, Patrice ;
Hernandez, Adrian F. ;
Braunwald, Eugene .
JAMA CARDIOLOGY, 2017, 2 (09) :950-958
[2]  
CEREMUZYNSKI L, 1983, INT J CLIN PHARM TH, V21, P417
[3]  
CRISTODORESCU R, 1977, REV ROUM MED-MED INT, V15, P27
[4]   Clinical benefits of eplerenone in patients with systolic heart failure and mild symptoms when initiated shortly after hospital discharge: analysis from the EMPHASIS-HF trial [J].
Girerd, Nicolas ;
Collier, Tim ;
Pocock, Stuart ;
Krum, Henry ;
McMurray, John J. ;
Swedberg, Karl ;
Van Veldhuisen, Dirk J. ;
Vincent, John ;
Pitt, Bertram ;
Zannad, Faiez .
EUROPEAN HEART JOURNAL, 2015, 36 (34) :2310-2317
[5]   Serum aldosterone is associated with mortality and re-hospitalization in patients with reduced ejection fraction hospitalized for acute heart failure: analysis from the EVEREST trial [J].
Girerd, Nicolas ;
Pang, Peter S. ;
Swedberg, Karl ;
Fought, Angela ;
Kwasny, Mary J. ;
Subacius, Haris ;
Konstam, Marvin A. ;
Maggioni, Aldo ;
Gheorghiade, Mihai ;
Zannad, Faiez .
EUROPEAN JOURNAL OF HEART FAILURE, 2013, 15 (11) :1228-1235
[6]   Angiotensin-converting-enzyme inhibitors in hemodynamic congestion: a meta-analysis of early studies [J].
Jobs, Alexander ;
Abdin, Amr ;
de Waha-Thiele, Suzanne ;
Eitel, Ingo ;
Thiele, Holger ;
de Wit, Cor ;
Vonthein, Reinhard .
CLINICAL RESEARCH IN CARDIOLOGY, 2019, 108 (11) :1240-1248
[7]  
OVERDIEK H W P M, 1987, Reviews on Drug Metabolism and Drug Interactions, V5, P273
[8]   Impact of eplerenone on cardiovascular outcomes in heart failure patients with hypokalaemia [J].
Rossignol, Patrick ;
Girerd, Nicolas ;
Bakris, George ;
Vardeny, Orly ;
Claggett, Brian ;
McMurray, John J. V. ;
Swedberg, Karl ;
Krum, Henry ;
van Veldhuisen, Dirk J. ;
Shi, Harry ;
Spanyers, Sean ;
Vincent, John ;
Fay, Renaud ;
Lamiral, Zohra ;
Solomon, Scott D. ;
Zannad, Faiez ;
Pitt, Bertram .
EUROPEAN JOURNAL OF HEART FAILURE, 2017, 19 (06) :792-799
[9]   Worsening kidney function in decompensated heart failure: treat the heart, dont mind the kidney [J].
Ruggenenti, Piero ;
Remuzzi, Giuseppe .
EUROPEAN HEART JOURNAL, 2011, 32 (20) :2476-2478
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