Porcine Reproductive and Respiratory Syndrome Virus (PRRSV): Pathogenesis and Interaction with the Immune System

被引：574

作者：

Lunney, Joan K. ^{[1
]}

Fang, Ying ^{[2
]}

Ladinig, Andrea ^{[3
]}

Chen, Nanhua ^{[2
,4
]}

Li, Yanhua ^{[2
]}

Rowland, Bob ^{[2
]}

Renukaradhya, Gourapura J. ^{[5
]}

机构：

[1] ARS, Anim Parasit Dis Lab, BARC, USDA, Beltsville, MD 20705 USA

[2] Kansas State Univ, Coll Vet Med, Manhattan, KS 66506 USA

[3] Univ Vet Med, A-1210 Vienna, Austria

[4] Yangzhou Univ, Coll Vet Med, Yangzhou 225009, Jiangsu, Peoples R China

[5] Ohio State Univ, FAHRP OARDC, Wooster, OH 44691 USA

来源：

ANNUAL REVIEW OF ANIMAL BIOSCIENCES, VOL 4 | 2016年 / 4卷

基金：

美国食品与农业研究所;

关键词：

PRRSV; porcine reproductive and respiratory syndrome; host immunity; genetic control; fetal infection; vaccine responses; BLOOD MONONUCLEAR-CELLS; REGULATORY T-CELLS; MYSTERY SWINE DISEASE; INFECTED IN-UTERO; PERIPHERAL-BLOOD; HOST RESPONSE; UP-REGULATION; PREGNANT GILTS; VIRAL LOAD; B-CELL;

D O I：

10.1146/annurev-animal-022114-111025

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

This review addresses important issues of porcine reproductive and respiratory syndrome virus (PRRSV) infection, immunity, pathogenesis, and control. Worldwide, PRRS is the most economically important infectious disease of pigs. We highlight the latest information on viral genome structure, pathogenic mechanisms, and host immunity, with a special focus on immune factors that modulate PRRSV infections during the acute and chronic/persistent disease phases. We address genetic control of host resistance and probe effects of PRRSV infection on reproductive traits. A major goal is to identify cellular/viral targets and pathways for designing more effective vaccines and therapeutics. Based on progress in viral reverse genetics, host transcriptomics and genomics, and vaccinology and adjuvant technologies, we have identified new areas for PRRS control and prevention. Finally, we highlight the gaps in our knowledge base and the need for advanced molecular and immune tools to stimulate PRRS research and field applications.

引用

页码：129 / 154

页数：26

共 152 条

[21] Regulatory T Cells in Arterivirus and Coronavirus Infections: Do They Protect Against Disease or Enhance it? [J].

Cecere, Thomas E. ;

Todd, S. Michelle ;

LeRoith, Tanya .

VIRUSES-BASEL, 2012, 4 (05) :833-846

[22] Up-regulation of pro-inflammatory factors by HP-PRRSV infection in microglia: Implications for HP-PRRSV neuropathogenesis [J].

Chen, Xin-xin ;

Quan, Rong ;

Guo, Xue-kun ;

Gao, Li ;

Shi, Jishu ;

Feng, Wen-hai .

VETERINARY MICROBIOLOGY, 2014, 170 (1-2) :48-57

[23] Identification of two auto-cleavage products of nonstructural protein 1 (nsp1) in porcine reproductive and respiratory syndrome virus infected cells: nsp1 function as interferon antagonist [J].

Chen, Z. ;

Lawson, S. ;

Sun, Z. ;

Zhou, X. ;

Guan, X. ;

Christopher-Hennings, J. ;

Nelson, E. A. ;

Fang, Y. .

VIROLOGY, 2010, 398 (01) :87-97

[24] Comparison of virus isolation, reverse transcription-polymerase chain reaction, immunohistochemistry, and in situ hybridization for the detection of porcine reproductive and respiratory syndrome virus from naturally aborted fetuses and stillborn piglets [J].

Cheon, DS ;

Chae, C .

JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 2000, 12 (06) :582-587

[25] Distribution of porcine reproductive and respiratory syndrome virus in stillborn and liveborn piglets from experimentally infected sows [J].

Cheon, DS ;

Chae, C .

JOURNAL OF COMPARATIVE PATHOLOGY, 2001, 124 (04) :231-237

[26]

CHRISTIANSON WT, 1993, CAN J VET RES, V57, P262

[27]

Christopher-Hennings Jane, 2008, Animal Health Research Reviews, V9, P59, DOI 10.1017/S1466252307001387

[28] Integrated miRNA and mRNA transcriptomes of porcine alveolar macrophages (PAM cells) identifies strain-specific miRNA molecular signatures associated with H-PRRSV and N-PRRSV infection [J].

Cong, Peiqing ;

Xiao, Shuqi ;

Chen, Yaosheng ;

Wang, Liangliang ;

Gao, Jintao ;

Li, Ming ;

He, Zuyong ;

Guo, Yunxue ;

Zhao, Guangyin ;

Zhang, Xiaoyu ;

Chen, Luxi ;

Mo, Delin ;

Liu, Xiaohong .

MOLECULAR BIOLOGY REPORTS, 2014, 41 (09) :5863-5875

[29] Functional impairment of PRRSV-specific peripheral CD3+CD8high cells [J].

Costers, Sarah ;

Lefebvre, David J. ;

Goddeeris, Bruno ;

Delputte, Peter L. ;

Nauwynck, Hans J. .

VETERINARY RESEARCH, 2009, 40 (05)

[30]

Croy BA, 2006, IMMUNOL REV, V214, P161

← 1 2 3 4 5 6 7 8 9 10 →