Refined localization of the Escherichia coli F4ab/F4ac receptor locus on pig chromosome 13

被引：21

作者：

Joller, D. ^{[1
]}

Jorgensen, C. B. ^{[2
]}

Bertschinger, H. U. ^{[1
]}

Python, P. ^{[3
]}

Edfors, I. ^{[4
]}

Cirera, S. ^{[2
]}

Archibald, A. L. ^{[5
,6
]}

Buergi, E. ^{[7
]}

Karlskov-Mortensen, P. ^{[2
]}

Andersson, L. ^{[8
]}

Fredholm, M. ^{[2
]}

Voegeli, P. ^{[1
]}

机构：

[1] ETH, Inst Anim Sci, CH-8092 Zurich, Switzerland

[2] Univ Copenhagen, Dept Basic Anim & Vet Sci, DK-1870 Frederiksberg, Denmark

[3] Agridea, CH-1006 Lausanne, Switzerland

[4] Univ Kalmar, Sch Pure & Appl Nat Sci, S-39182 Kalmar, Sweden

[5] Roslin Inst, Div Genet & Genom, Roslin EH25 9PS, Midlothian, Scotland

[6] Univ Edinburgh, RDSVS, Roslin EH25 9PS, Midlothian, Scotland

[7] Univ Zurich, Dept Farm Anim, CH-8057 Zurich, Switzerland

[8] Uppsala Univ, Dept Med Biochem & Microbiol, S-75123 Uppsala, Sweden

来源：

ANIMAL GENETICS | 2009年 / 40卷 / 05期

基金：

英国生物技术与生命科学研究理事会; 瑞士国家科学基金会;

关键词：

chromosome; 13; enterotoxigenic Escherichia coli; Escherichia coli; F4ab; F4ac receptor; linkage mapping; pig; INTESTINAL RECEPTOR; MAP; INHERITANCE; DIARRHEA; LINKAGE; GENOME; GENES; K88AB; SWINE; F4AC;

D O I：

10.1111/j.1365-2052.2009.01881.x

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

P>Diarrhoea in newborn and weaned pigs caused by enterotoxigenic Escherichia coli (ETEC) expressing F4 fimbriae leads to considerable losses in pig production. In this study, we refined the mapping of the receptor locus for ETEC F4ab/F4ac adhesion (F4bcR) by joint analysis of Nordic and Swiss data. A total of 236 pigs from a Nordic experimental herd, 331 pigs from a Swiss experimental herd and 143 pigs from the Swiss performing station were used for linkage analysis. Genotyping data of six known microsatellite markers, two newly developed markers (MUC4gt and HSA125gt) and an intronic SNP in MUC4 (MUC4-8227) were used to create the linkage map. The region for F4bcR was refined to the interval SW207-S0075 on pig chromosome 13. The most probable position of F4bcR was in the SW207-MUC4 region. The order of six markers was supported by physical mapping on the BAC fingerprint contig from the Wellcome Trust Sanger Institute. Thus, the region for F4bcR could be reduced from 26 to 14 Mb.

引用

页码：749 / 752

页数：4

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