Telomerase unplugged

被引：14
作者：
Cristofari, Gael
Sikora, Katarzyna
Lingner, Joachim [1 ]
机构：
[1] Ecole Polytech Fed Lausanne, Swiss Inst Expt Canc Res, CH-1066 Epalinges, Switzerland
[2] NCCR, Program Frontiers Genet, CH-1066 Epalinges, Switzerland
来源：
ACS CHEMICAL BIOLOGY | 2007年 / 2卷 / 03期
关键词：
D O I：
10.1021/cb700037c
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The control of telomerase activity at chromosome ends by telomere-binding proteins is critical for telomere length homeostasis. Two recent papers identify TPP1 as a critical mediator of this control. TPP1 forms part of the telomeric shelterin complex while also associating with telomerase, stimulating its activity and processivity.
引用
收藏
页码：155 / 158
页数：4
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