Molecular analysis of katG gene mutations in strains of Mycobacterium tuberculosis complex from Africa

被引：100

作者：

Haas, WH

Schilke, K

Brand, J

Amthor, B

Weyer, K

Fourie, PB

Bretzel, G

StichtGroh, V

Bremer, HJ

机构：

[1] GERMAN LEPROSY RELIEF ASSOC,ARMAUER HANSEN RES INST,MYCOBACTERIOL LAB,WURZBURG,GERMANY

[2] S AFRICAN MRC,TB RES INST,PRETORIA,SOUTH AFRICA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 07期

关键词：

D O I：

10.1128/AAC.41.7.1601

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A sample of 124 isoniazid (INH)-resistant and 88 susceptible strains of Mycobacterium tuberculosis complex from south, central, and west Africa was analyzed by direct sequence analysis and PCR-restriction fragment length polymorphism analysis of their catalase-peroxidase (katG) genes. Point mutations at codon 315 were found in the genomes of 64% of INH-resistant strains, but no complete deletions were identified. Mutations at codon 463 were independent of INH resistance and were linked to the geographic origins of the strains.

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页码：1601 / 1603

页数：3

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