Are Animal Models of Pulmonary Hypertension Relevant to the Clinical Disease?

被引:3
作者
Rubin, Lewis J. [1 ]
机构
[1] Univ Calif San Diego, Div Pulm & Crit Care Med, 5550 Caminito Genio, La Jolla, CA 92037 USA
关键词
aerosol delivery; gene therapy; pig models; pulmonary vascular remodeling; right ventricular function; ARTERIAL-HYPERTENSION; PROSTACYCLIN;
D O I
10.1016/j.jacc.2016.03.002
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:2047 / 2049
页数:3
相关论文
共 9 条
[1]   Intratracheal Gene Delivery of SERCA2a Ameliorates Chronic Post-Capillary Pulmonary Hypertension A Large Animal Model [J].
Aguero, Jaume ;
Ishikawa, Kiyotake ;
Hadri, Lahouaria ;
Santos-Gallego, Carlos G. ;
Fish, Kenneth M. ;
Kohlbrenner, Erik ;
Hammoudi, Nadjib ;
Kho, Changwon ;
Lee, Ahyoung ;
Ibanez, Borja ;
Garcia-Alvarez, Ana ;
Zsebo, Krisztina ;
Maron, Bradley A. ;
Plataki, Maria ;
Fuster, Valentin ;
Leopold, Jane A. ;
Hajjar, Roger J. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 67 (17) :2032-2046
[2]   Initial Use of Ambrisentan plus Tadalafil in Pulmonary Arterial Hypertension [J].
Galie, N. ;
Barbera, J. A. ;
Frost, A. E. ;
Ghofrani, H-A. ;
Hoeper, M. M. ;
McLaughlin, V. V. ;
Peacock, A. J. ;
Simonneau, G. ;
Vachiery, J-L. ;
Gruenig, E. ;
Oudiz, R. J. ;
Vonk-Noordegraaf, A. ;
White, R. J. ;
Blair, C. ;
Gillies, H. ;
Miller, K. L. ;
Harris, J. H. N. ;
Langley, J. ;
Rubin, L. J. .
NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (09) :834-844
[3]   Attenuation of Monocrotaline-Induced Pulmonary Hypertension by Luminal Adeno-Associated Virus Serotype 9 Gene Transfer of Prostacyclin Synthase [J].
Gubrij, Igor B. ;
Martin, Sara Rebecca ;
Pangle, Amanda K. ;
Kurten, Richard ;
Johnson, Larry G. .
HUMAN GENE THERAPY, 2014, 25 (06) :498-505
[4]   Therapeutic Efficacy of AAV1.SERCA2a in Monocrotaline-Induced Pulmonary Arterial Hypertension [J].
Hadri, Lahouaria ;
Kratlian, Razmig G. ;
Benard, Ludovic ;
Maron, Bradley A. ;
Dorfmueller, Peter ;
Ladage, Dennis ;
Guignabert, Christophe ;
Ishikawa, Kiyotake ;
Aguero, Jaume ;
Ibanez, Borja ;
Turnbull, Irene C. ;
Kohlbrenner, Erik ;
Liang, Lifan ;
Zsebo, Krisztina ;
Humbert, Marc ;
Hulot, Jean-Sebastien ;
Kawase, Yoshiaki ;
Hajjar, Roger J. ;
Leopold, Jane A. .
CIRCULATION, 2013, 128 (05) :512-U119
[5]   Pulmonary veno-occlusive disease [J].
Mandel, J ;
Mark, EJ ;
Hales, CA .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2000, 162 (05) :1964-1973
[6]   Addition of sildenafil to long-term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: a randomized trial (vol 149, pg 521, 2008) [J].
Simonneau, G. ;
Rubin, L. J. ;
Galie, N. ;
Barst, R. J. ;
Fleming, T. R. ;
Frost, A. E. .
ANNALS OF INTERNAL MEDICINE, 2009, 151 (06) :435-435
[7]   Long-term response to calcium channel blockers in idiopathic pulmonary arterial hypertension [J].
Sitbon, O ;
Humbert, M ;
Jaïs, X ;
Ioos, V ;
Hamid, AM ;
Provencher, S ;
Garcia, G ;
Parent, F ;
Hervé, P ;
Simonneau, G .
CIRCULATION, 2005, 111 (23) :3105-3111
[8]   INHALED NITRIC-OXIDE AS A SCREENING VASODILATOR AGENT IN PRIMARY PULMONARY-HYPERTENSION - A DOSE-RESPONSE STUDY AND COMPARISON WITH PROSTACYCLIN [J].
SITBON, O ;
BRENOT, F ;
DENJEAN, A ;
BERGERON, A ;
PARENT, F ;
AZARIAN, R ;
HERVE, P ;
RAFFESTIN, B ;
SIMONNEAU, G .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1995, 151 (02) :384-389
[9]  
Tuder RM, 2004, PULM CIRC, P25