Synthesis and enzyme inhibition study of unnatural saturated and unsaturated C-alkyl pyrrolidine iminosugars from D-mannose derived nitrone

被引：10

作者：

Das, Pintu ^{[1
]}

Kundooru, Somireddy ^{[1
]}

Pandole, Ravikant ^{[1
]}

Sharma, Sandeep K. ^{[2
]}

Singh, Bhupendra N. ^{[2
]}

Shaw, Arun K. ^{[1
]}

机构：

[1] CSIR Cent Drug Res Inst, Div Med & Proc Chem, Lucknow 226031, Uttar Pradesh, India

[2] CSIR Cent Drug Res Inst, Div Microbiol, Lucknow 226031, Uttar Pradesh, India

来源：

TETRAHEDRON-ASYMMETRY | 2016年 / 27卷 / 2-3期

关键词：

ALPHA-GLUCOSIDASE INHIBITORS; TYPE-2; DIABETES-MELLITUS; CYCLIC NITRONES; GLYCOSIDASE INHIBITORS; NATURAL OCCURRENCE; GENERAL-SYNTHESIS; VERSATILE ACCESS; RADICAMINE-B; CYCLOADDITION; DESIGN;

D O I：

10.1016/j.tetasy.2015.12.003

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The C-alkylated biologically important pyrrolidine iminosugars have been synthesized from commercially available D-mannose. The key step of this strategy involves the diastereoselective Grignard addition to D-mannose derived nitrone 7. These unnatural iminosugars have also been tested against several glycosidases and some of them showed weak inhibition against some glucosidases. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：101 / 106

页数：6

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