Promising antibacterial agents against multidrug resistant Staphylococcus aureus

被引：48

作者：

Gatadi, Srikanth ^{[1
]}

Madhavi, Y., V ^{[1
]}

Chopra, Sidharth ^{[2
]}

Nanduri, Srinivas ^{[1
]}

机构：

[1] NIPER, Dept Med Chem, Hyderabad 500037, Andhra Pradesh, India

[2] CSIR Cent Drug Res Inst, Div Microbiol, Sitapur Rd,Sect 10, Lucknow 226031, Uttar Pradesh, India

来源：

BIOORGANIC CHEMISTRY | 2019年 / 92卷

关键词：

Antibacterial agents; Multidrug resistant Staphylococcus aureus; Minimum inhibitory concentration; Vero cells; BETA-LACTAM ANTIBIOTICS; DNA-BINDING LIGANDS; METHICILLIN-RESISTANT; ANTIMICROBIAL RESISTANCE; IN-VITRO; PLEUROMUTILIN DERIVATIVES; TOPOISOMERASE INHIBITORS; BIOLOGICAL EVALUATION; CRTN INHIBITORS; HIGHLY POTENT;

D O I：

10.1016/j.bioorg.2019.103252

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rapid emergence of multidrug resistant Staphylococcus aureus infections has created a critical health menace universally. Resistance to all the available chemotherapeutics has been on rise which led to WHO to stratify Staphylococcus aureus as high tier priorty II pathogen. Hence, discovery and development of new antibacterial agents with new mode of action is crucial to address the multidrug resistant Staphylococcus aureus infections. The egressing understanding of new antibacterials on their biological target provides opportunities for new therapeutic agents. This review underlines on various aspects of drug design, structure activity relationships (SARs) and mechanism of action of various new antibacterial agents and also covers the recent reports on new antibacterial agents with potent activity against multidrug resistant Staphylococcus aureus. This review provides attention on in vitro and in vivo pharmacological activities of new antibacterial agents in the point of view of drug discovery and development.

引用

页数：23

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