Clinical impact of aneuploidy on gastric cancer patients

被引：12
作者：
Sanchez-Perez, Isabel [1 ]
Garcia Alonso, Pilar [2 ]
Belda Iniesta, Cristobal [3 ]
机构：
[1] Inst Invest Biomed CSIC UAM, Translat Oncol Unit, ES-28029 Madrid, Spain
[2] Hosp Gen Gregorio Maranon, Med Oncol Serv, Madrid, Spain
[3] Univ Autonoma Madrid, RETICC, Translat Oncol Unit CSIC UAM, Div Med Oncol,Univ Hosp La Paz,Sch Med, Madrid, Spain
来源：
CLINICAL & TRANSLATIONAL ONCOLOGY | 2009年 / 11卷 / 08期
关键词：
Chromosome mis-segregation; Mitotic checkpoint; Gastric cancer; Cell cycle; Prognosis; S-PHASE FRACTION; MEROTELIC KINETOCHORE ORIENTATION; MITOTIC CHECKPOINT GENES; AURORA KINASE; DNA-PLOIDY; FLOW-CYTOMETRY; KINESIN OVEREXPRESSION; CHROMOSOME INSTABILITY; PROLIFERATIVE ACTIVITY; CHROMATID SEPARATION;
D O I：
10.1007/s12094-009-0393-z
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Gastric cancer is a leading cause of death worldwide. Nowadays, complete surgical resection and TNM at diagnosis are the main prognostic factors. In spite of this, many patients will have a recurrence after surgery and die within a few months or years. That means that we need more accurate prognostic factors to design specific approaches for individual patients. Chromosome instability is a feature of gastric cancer commonly associated to chromosomal aberrations that leads to major modifications of DNA content globally termed as aneuploidy. In this regard, many authors' opinions diverge regarding the clinical impact of aneuploidy. This review will summarise data on the clinical impact of aneuploidy on clinical practice, the biological mechanisms that underlie chromosomal instability that induces aneuploidy and the relevance of specific chromosomal aneuploidy to cancer biology.
引用
收藏
页码：493 / 498
页数：6
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