共 69 条
Synthesis of Ring-Fused Oxazolo- and Pyrazoloisoquinolinones by a One-Pot Pd-Catalyzed Carboxamidation and Aldol-Type Condensation Cascade Process
被引:28
作者:

Chouhan, Gagan
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada

Alper, Howard
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada
机构:
[1] Univ Ottawa, Dept Chem, Ctr Catalysis Res & Innovat, Ottawa, ON K1N 6N5, Canada
基金:
加拿大自然科学与工程研究理事会;
关键词:
CARBONYLATIVE CYCLIZATION;
MULTICOMPONENT SYNTHESIS;
CYTOTOXIC ANTIBIOTICS;
ORGANIC-SYNTHESIS;
PALLADIUM;
HETEROCYCLES;
DERIVATIVES;
ISOQUINOLINES;
INHIBITORS;
ANNULATION;
D O I:
10.1021/jo9010574
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
A three-component cascade process is described for the synthesis of ring-fused oxazolo- and pyrazoloisoquinolinones by a one-pot carboxamidation/aldol-type condensation reaction. The cascade process involves Pd-catalyzed carboxamidation of an aryl halide/active methylene compound with oxazolidinone or pyrazolidinone, and subsequent intramolecular base-catalyzed cyclization/dehydration through an aldol-type condensation process, to give ring-fused oxazolo- and pyrazoloisoquinolinones. This methodology provides an easy one-step approach to these important classes of nitrogen-containing heterocycles and can tolerate it wide array of functional groups, including ester, nitrile, methoxy, and halide.
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收藏
页码:6181 / 6189
页数:9
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