Selective Ketone Formations via Cobalt-Catalyzed β-Alkylation of Secondary Alcohols with Primary Alcohols

被引：48

作者：

Pandey, Bedraj ^{[1
]}

Xu, Shi ^{[1
]}

Ding, Keying ^{[1
,2
]}

机构：

[1] Middle Tennessee State Univ, Dept Chem, Murfreesboro, TN 37132 USA

[2] Middle Tennessee State Univ, Mol Biosci Program, Murfreesboro, TN 37132 USA

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 18期

基金：

美国国家科学基金会;

关键词：

BORROWING-HYDROGEN; ALPHA-ALKYLATION; AROMATIC-AMINES; N-ALKYLATION; EFFICIENT CATALYSTS; PINCER COMPLEXES; METHYLATION; IMINES; DEHYDROGENATION; METALS;

D O I：

10.1021/acs.orglett.9b02727

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A homogeneous cobalt-catalyzed beta-alkylation of secondary alcohols with primary alcohols to selectively synthesize ketones via acceptorless dehydrogenative coupling is reported for the first time. Notably, this transformation is environmentally benign and atom economical with water and hydrogen gas as the only byproducts.

引用

页码：7420 / 7423

页数：4

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