Iron-Catalyzed Radical Methylation of Activated Alkenes with tert -Butanol as the Methyl Source

被引：5

作者：

Xu, Zhengbao ^{[1
,3
]}

Jia, Rui ^{[2
]}

Ma, Zhiwei ^{[3
]}

Cao, Shouhao ^{[3
]}

Shen, Liang ^{[1
,3
]}

Ji, Hongfang ^{[1
,3
]}

机构：

[1] Shandong Univ Technol, Inst Biomed Res, Zibo 255000, Shandong, Peoples R China

[2] Zibo Meteorol Bur, Zibo 255000, Shandong, Peoples R China

[3] Shandong Univ Technol, Shandong Prov Res Ctr Bioinformat Engn & Tech, Sch Life Sci, Zibo Key Lab New Drug Dev Neurodegenerat Dis, Zibo 255000, Shandong, Peoples R China

来源：

SYNLETT | 2019年 / 30卷 / 16期

关键词：

methylation; oxinidoles; quinones; arylacrylamides; cascade reaction; C-H BONDS; SELECTIVE ALKYLATION; N-ARYLACRYLAMIDES; OXINDOLES; CASCADE; FUNCTIONALIZATION; DERIVATIVES; IDENTIFICATION; OXIDATION; QUINONES;

D O I：

10.1055/s-0039-1690193

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A free-radical-initiated methylation/addition/cyclization of N -arylacrylamides and a methylation/addition/elimination of quinines have been developed in which t -BuOH is used as a methyl source. These reactions provide effective and selective methods for the synthesis of various methylated oxindoles and quinones in moderate to good yields.

引用

页码：1909 / 1913

页数：5

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