Glucosylation of cinobufagin by cultured suspension cells of Catharanthus roseus

被引：49
|
作者：
Ye, M [1 ]
Dal, JG [1 ]
Guo, HZ [1 ]
Cui, YJ [1 ]
Guo, D [1 ]
机构：
[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
来源：
TETRAHEDRON LETTERS | 2002年 / 43卷 / 47期
基金：
美国国家科学基金会;
关键词：
biotransformation; cinobufagin; Catharanthus roseus; cell suspension culture; glucosylation;
D O I：
10.1016/S0040-4039(02)02078-6
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
biotransformation of cinobufagin by cell suspension cultures Of Catharanthus roseus was investigated. After 6 days incubation, four new glucosylated derivatives, desacetylcinobufagin 16-O-beta-D-glucoside, 3-epi-desacetylcinobufagin 16-O-beta-D-glucoside, 3-oxo-desacetylcinobufagin 16-O-beta-D-glucoside, and cinobufagin 3-O-beta-D-glucoside, respectively, were isolated and identified on the basis of their physical and chemical data. This is the first report of bufadienolides with a glucosyl substituent at the C-16 position. (C) 2002 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：8535 / 8538
页数：4
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