Asymmetric construction of quaternary carbon stereocenter by Pd-catalyzed intramolecular α-arylation

被引：31

作者：

Arao, Takafumi ^{[1
]}

Kondo, Kazuhiro ^{[1
]}

Aoyama, Toyohiko ^{[1
]}

机构：

[1] Nagoya City Univ, Grad Sch Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 4678603, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2006年 / 54卷 / 12期

关键词：

enantioselective intramolecular alpha-arylation; quaternary carbon; H-8-BINAP; chiral N-heterocyclic carbene;

D O I：

10.1248/cpb.54.1743

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The catalyst comprised of Pd(OAc)(2) and H-8-BINAP provides good reaction conversions for a catalytic enantioselective intramolecular alpha-arylation of N-(2-bromophenyl)-N-methyl-2-arylpropanamide to form the quaternary carbon with up to 68% enantioselectivity.

引用

页码：1743 / 1747

页数：5

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