An Overview on Marek's Disease Virus Evolution and Evidence for Increased Virulence in Brazil

被引：7

作者：

Torres, A. C. D. ^{[1
]}

Marin, S. Y. ^{[1
]}

Costa, C. S. ^{[1
]}

Martins, N. R. S. ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Dept Med Vet Prevent, Escola Vet, Ave Antonio Carlos 6627, BR-31270901 Belo Horizonte, MG, Brazil

来源：

BRAZILIAN JOURNAL OF POULTRY SCIENCE | 2019年 / 21卷 / 01期

关键词：

Gallid herpesvirus 2; Marek's disease virus; Gallus gallus domesticus; meq gene; virulence; MOLECULAR CHARACTERIZATION; VIRAL-ANTIGEN; FIELD STRAINS; CELL-FREE; MEQ GENE; HERPESVIRUS; CHICKENS; ONCOGENICITY; VACCINATION; MDV;

D O I：

10.1590/1806-9061-2018-0870

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Marek's disease virus (MDV) has been shown to be evolving to higher virulence. One of the genetic sites involved in virulence which enables such characterization is the 339-amino acid Meq protein encoding gene (meq). The reemergence of clinical Marek's disease (MD) in vaccinated flocks can be associated to changes in meq. Our studies have shown the presence of very virulent MDV strains in the Brazilian industrial and free-range poultry. We present an overview of MD increasing severity and indicate the necessity of using phylogenetic tools for best accompanying MDV evolution.

引用

页数：9

共 84 条

[1] Pathological Aspects of a Subclinical Marek's Disease Case in Free-Range Chickens [J].

Abreu, D. L. C. ;

Santos, F. F. ;

Jose, D. S. ;

Tortelly, R. ;

Nascimento, E. R. ;

Pereira, V. L. A. .

BRAZILIAN JOURNAL OF POULTRY SCIENCE, 2016, 18 (01) :197-199

[2]

[Anonymous], 2011, ICTV REP

[3] VACCINATION AND REDUCED COHORT DURATION CAN DRIVE VIRULENCE EVOLUTION: MAREK'S DISEASE VIRUS AND INDUSTRIALIZED AGRICULTURE [J].

Atkins, Katherine E. ;

Read, Andrew F. ;

Savill, Nicholas J. ;

Renz, Katrin G. ;

Islam, A. F. M. Fakhrul ;

Walkden-Brown, Stephen W. ;

Woolhouse, Mark E. J. .

EVOLUTION, 2013, 67 (03) :851-860

[4] Differential susceptibility to Marek's disease is associated with differences in number, but not phenotype or location, of pp38+ lymphocytes [J].

Baigent, SJ ;

Ross, LJN ;

Davison, TF .

JOURNAL OF GENERAL VIROLOGY, 1998, 79 :2795-2802

[5]

Baigent SJ., 2004, Marek's disease, P62, DOI [10.1016/B978-012088379-0/50010-4, DOI 10.1016/B978-012088379-0/50010-4]

[6] Relationship Between Levels of Very Virulent MDV in Poultry Dust and in Feather Tips from Vaccinated Chickens [J].

Baigent, Susan J. ;

Kgosana, Lydia B. ;

Gamawa, Ahmed A. ;

Smith, Lorraine P. ;

Read, Andrew F. ;

Nair, Venugopal K. .

AVIAN DISEASES, 2013, 57 (02) :440-447

[7]

BEASLEY JN, 1970, AM J VET RES, V31, P339

[8]

BENTON W. J., 1957, AVIAN DIS, V1, P320, DOI 10.2307/1587746

[9]

Biggs P. M., 1972, Oncogenesis and herpesviruses. Proceedings of a symposium held at Christ's College, Cambridge, England 20 to 25 June 1971., P88

[10]

Biggs PM, 1965, P 3 C WORLD VET POUL, P61

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