Molecular mechanisms of the physiological functions of the aryl hydrocarbon (dioxin) receptor, a multifunctional regulator that senses and responds to environmental stimuli

被引：91

作者：

Fujii-Kuriyama, Yoshiaki ^{[1
]}

Kawajiri, Kaname ^{[2
]}

机构：

[1] Tokyo Med Dent Univ, Med Res Inst, Tokyo, Japan

[2] Saitama Canc Ctr, Res Inst Clin Oncol, Saitama, Japan

来源：

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES | 2010年 / 86卷 / 01期

关键词：

bHLH-PAS transcription factor; innate immunity; reproduction; tumor suppression; ubiquitylation; environmental stimuli; AH-RECEPTOR; ESTROGEN-RECEPTOR; SIGNAL-TRANSDUCTION; P-450C GENE; 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD; ARYLHYDROCARBON RECEPTOR; MEDIATED TRANSCRIPTION; INDUCIBLE EXPRESSION; NUCLEOTIDE-SEQUENCE; HEPATIC CYTOSOL;

D O I：

10.2183/pjab.86.40

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The aryl hydrocarbon receptor (AhR) was originally identified as a ligand-activated transcription factor that is involved in the induction of xenobiotic-metabolizing Cytochrome P4501A1 (CYP1A1). For several decades, AhR has been studied in relation to toxicology and pharmacology. With recent discoveries on novel AhR functions, AhR research has expanded into multiple aspects of physiology, such as reproduction, innate immunity and tumor suppression. In this review, we summarize and discuss recent progress in mechanistic and functional studies on AhR with particular emphasis on physiological processes.

引用

页码：40 / 53

页数：14

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