Cyproterone acetate displaces opiate binding in mouse brain

被引：5

作者：

Gutierrez, M ^{[1
]}

Menendez, L ^{[1
]}

RuizGayo, M ^{[1
]}

Hidalgo, A ^{[1
]}

Baamonde, A ^{[1
]}

机构：

[1] FAC MED,DEPT MED,FARMACOL LAB,OVIEDO 33071,SPAIN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1997年 / 328卷 / 01期

关键词：

opioid; steroid; cyproterone acetate; binding;

D O I：

10.1016/S0014-2999(97)83034-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Drugs acting on androgen receptors modify opioid transmission in the central nervous system. To investigate a direct interaction, we studied whether the binding of [H-3]diprenorphine to mouse brain membranes was modified by cyproterone acetate (progesterone derivative with antiandrogen activity), flutamide (non-steroidal antiandrogen), 5 alpha-dihydrotestosterone and progesterone. Only cyproterone acetate inhibited [H-3]diprenorphine binding (IC50 = (1.62 +/- 0.33) x 10(-6) M) without modifying its association rate. These results suggest that cyproterone acetate binds to opiate receptors independently of its classical androgenic intracellular receptor effect.

引用

收藏

页码：99 / 102

页数：4

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