METFORMIN-ASSOCIATED LACTIC ACIDOSIS PRESENTING LIKE ACUTE MESENTERIC ISCHEMIA

被引:7
作者
Zhang, Qi Charles [1 ]
Hastings, Casey [1 ]
Johnson, Kelly [1 ]
Slaven, Ellen [1 ]
机构
[1] LSU Emergency Med Residency, Dept Emergency Med, Univ Med Ctr, 2001 Tulane Ave,D&T Bldg,Suite 2720, New Orleans, LA 70112 USA
关键词
mesenteric ischemia; metformin; metformin-associated lactic acidosis; lactic acidosis;
D O I
10.1016/j.jemermed.2019.04.024
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Background: Metformin-associated lactic acidosis is a rare but serious complication of taking metformin. Making the diagnosis in the emergency department requires vigilance because the presentation can mimic other diseases. Case Report: We present a case of a patient with diabetes who presented moribund with symptoms and signs consistent with mesenteric ischemia. This diagnosis was seemingly confirmed through computed tomography, and as a result the patient was brought to surgery for emergent exploratory laparotomy. Our patient made a remarkable recovery upon initiation of hemodialysis, demonstrating the need to initiate this life-saving procedure early. Why Should an Emergency Physician be Aware of This?: Metformin levels are rarely available in the setting of the emergency department. Clinicians must remain alert, recognize that imaging studies may be misleading, and consider hemodialysis early in addition to surgical interventions. (C) 2019 Elsevier Inc. All rights reserved.
引用
收藏
页码:720 / 722
页数:3
相关论文
共 12 条
  • [1] Ali S, 2018, BMJ CASE REP, V2018
  • [2] Metformin associated lactic acidosis: a case series of 28 patients treated with sustained low-efficiency dialysis (SLED) and long-term follow-up
    Angioi, Andrea
    Cabiddu, Gianfranca
    Conti, Maura
    Pili, Gianfranco
    Atzeni, Alice
    Matta, Valeria
    Cao, Riccardo
    Floris, Matteo
    Songini, Marco
    Mulas, Maria Franca
    Rosner, Mitchell
    Pani, Antonello
    [J]. BMC NEPHROLOGY, 2018, 19
  • [3] Boolani Hemant, 2011, J Atr Fibrillation, V4, P411, DOI 10.4022/jafib.411
  • [4] Bruijstens LA, 2008, NETH J MED, V66, P185
  • [5] Metformin-associated Lactic Acidosis Masquerading as Ischemic Bowel
    Correia, Chase S.
    Bronander, Kirk A.
    [J]. AMERICAN JOURNAL OF MEDICINE, 2012, 125 (05) : E9 - E9
  • [6] Metformin-associated lactic acidosis: Current perspectives on causes and risk
    DeFronzo, Ralph
    Fleming, G. Alexander
    Chen, Kim
    Bicsak, Thomas A.
    [J]. METABOLISM-CLINICAL AND EXPERIMENTAL, 2016, 65 (02): : 20 - 29
  • [7] Combined renal replacement therapy for severe metformin-induced lactic acidosis
    Friesecke, Sigrun
    Abel, Peter
    Kraft, Matthias
    Gerner, Andreas
    Runge, Soeren
    [J]. NEPHROLOGY DIALYSIS TRANSPLANTATION, 2006, 21 (07) : 2038 - 2039
  • [8] Metformin accumulation without hyperlactataemia and metformin-induced hyperlactataemia without metformin accumulation
    Lalau, J. D.
    Azzoug, M. L.
    Kajbaf, F.
    Briet, C.
    Desailloud, R.
    [J]. DIABETES & METABOLISM, 2014, 40 (03) : 220 - 223
  • [9] Metformin-associated lactic acidosis presenting as an ischemic gut in a patient who then survived a cardiac arrest: A case report
    Ncomanzi D.
    Sicat R.M.R.
    Sundararajan K.
    [J]. Journal of Medical Case Reports, 8 (1)
  • [10] Prolonged Hemodialysis: An Antidote for Metformin-Associated Lactic Acidosis
    Pallavi, Ranjita
    Chaudhari, Ashok
    [J]. AMERICAN JOURNAL OF THERAPEUTICS, 2016, 23 (02) : E606 - E608