Effects of inhibition of glycation and oxidative stress on the development of diabetic nephropathy in rats

被引：43

作者：

Agardh, CD

Stenram, U

Torffvit, O

Agardh, E

机构：

[1] Univ Hosp MAS, Wallenberg Res Lab, SE-20502 Malmo, Sweden

[2] Univ Lund Hosp, Dept Pathol, S-22185 Lund, Sweden

[3] Univ Lund Hosp, Dept Med, S-22185 Lund, Sweden

来源：

JOURNAL OF DIABETES AND ITS COMPLICATIONS | 2002年 / 16卷 / 06期

关键词：

aminoguanidine; probucol; albumin; tamm-horsfall protein; urine; nephropathy; diabetes; rat;

D O I：

10.1016/S1056-8727(02)00164-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated whether aminoguanidine (AG), an inhibitor of advanced glycated end product formation, or probucol (PB), a free radical scavenger, could influence signs of glomerular and distal tubular function and morphological changes in kidneys of male Wistar rats after 6 months of streptozoein (STZ)-induced diabetes. Diabetic rats had a higher kidney weight/body weight ratio (P < .001), but neither AG nor PB influenced the increased ratio. Diabetes caused an increased urinary albumin excretion (P < .05), which was normalized by AG, but further exaggerated by PB (P < .001). Diabetes also caused an increase in the urinary excretion of Tamm-Horsfall protein (P < .001). Both AG and PB attenuated this increase (P < .05 for both). A few glomeruli displayed focal thickening of varying degrees. Silver staining disclosed the glomerulopathy to be intercapillary glomerulosclerosis. Rats on PB-enriched diet displayed less pronounced changes than untreated rats (P < .01), while AG had no effect. The results suggest that oxidative stress could be involved in the development of diabetic nephropathy. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：395 / 400

页数：6

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