Detection of a SARS-CoV-2 variant of concern in South Africa

被引：1282

作者：

Tegally, Houriiyah ^{[1
]}

Wilkinson, Eduan ^{[1
]}

Giovanetti, Marta ^{[2
,3
]}

Iranzadeh, Arash ^{[4
]}

Fonseca, Vagner ^{[1
,3
]}

Giandhari, Jennifer ^{[1
]}

Doolabh, Deelan ^{[5
]}

Pillay, Sureshnee ^{[1
]}

San, Emmanuel James ^{[1
]}

Msomi, Nokukhanya ^{[6
,7
]}

Mlisana, Koleka ^{[8
,9
]}

von Gottberg, Anne ^{[10
,11
]}

Walaza, Sibongile ^{[10
,12
]}

Allam, Mushal ^{[10
]}

Ismail, Arshad ^{[10
]}

Mohale, Thabo ^{[10
]}

Glass, Allison J. ^{[11
,13
]}

Engelbrecht, Susan ^{[14
,15
]}

Van Zyl, Gert ^{[14
,15
]}

Preiser, Wolfgang ^{[14
,15
]}

Petruccione, Francesco ^{[16
,17
]}

Sigal, Alex ^{[18
,19
,20
]}

Hardie, Diana ^{[21
]}

Marais, Gert ^{[21
]}

Hsiao, Nei-Yuan ^{[21
]}

Korsman, Stephen ^{[21
]}

Davies, Mary-Ann ^{[22
,23
]}

Tyers, Lynn ^{[5
]}

Mudau, Innocent ^{[5
]}

York, Denis ^{[24
]}

Maslo, Caroline ^{[25
]}

Goedhals, Dominique ^{[26
]}

Abrahams, Shareef ^{[27
]}

Laguda-Akingba, Oluwakemi ^{[27
,28
]}

Alisoltani-Dehkordi, Arghavan ^{[29
,30
]}

Godzik, Adam ^{[30
]}

Wibmer, Constantinos Kurt ^{[10
]}

Sewell, Bryan Trevor ^{[31
]}

Lourenco, Jose ^{[32
]}

Alcantara, Luiz Carlos Junior ^{[2
,3
]}

Pond, Sergei L. Kosakovsky ^{[33
]}

Weaver, Steven ^{[33
]}

Martin, Darren ^{[4
,5
]}

Lessells, Richard J. ^{[1
,9
]}

Bhiman, Jinal N. ^{[10
,11
]}

Williamson, Carolyn ^{[5
,9
,21
]}

de Oliveira, Tulio ^{[1
,9
,34
]}

机构：

[1] Univ KwaZulu Natal, Sch Lab Med & Med Sci, KwaZulu Natal Res Innovat & Sequencing Platform K, Durban, South Africa

[2] Fundacao Oswaldo Cruz, Lab Flavivirus, Rio De Janeiro, Brazil

[3] Univ Fed Minas Gerais, Lab Genet Celular & Mol, Belo Horizonte, MG, Brazil

[4] Univ Cape Town, Dept Integrat Biomed Sci, Computat Biol Div, Cape Town, South Africa

[5] Univ Cape Town, Inst Infect Dis & Mol Med, Div Med Virol, Cape Town, South Africa

[6] Univ KwaZulu Natal, Sch Lab Med & Med Sci, Discipline Virol, Durban, South Africa

[7] Univ KwaZulu Natal, Natl Hlth Lab Serv NHLS, Durban, South Africa

[8] NHLS, Johannesburg, South Africa

[9] Ctr AIDS Programme Res South Africa CAPRISA, Durban, South Africa

[10] NHLS, Natl Inst Communicable Dis, Johannesburg, South Africa

[11] Univ Witwatersrand, Fac Hlth Sci, Sch Pathol, Johannesburg, South Africa

[12] Univ Witwatersrand, Fac Hlth Sci, Sch Publ Hlth, Johannesburg, South Africa

[13] Lancet Labs, Dept Mol Pathol, Johannesburg, South Africa

[14] Stellenbosch Univ, Fac Med & Hlth Sci, Div Med Virol, Cape Town, South Africa

[15] NHLS Tygerberg Hosp, Cape Town, South Africa

[16] Univ KwaZulu Natal, Ctr Quantum Technol, Durban, South Africa

[17] Univ KwaZulu Natal, Natl Inst Theoret Phys NITheP, Durban, South Africa

[18] Africa Hlth Res Inst, Durban, South Africa

[19] Univ KwaZulu Natal, Sch Lab Med & Med Sci, Durban, South Africa

[20] Max Planck Inst Infect Biol, Berlin, Germany

[21] Univ Cape Town, NHLS Groote Schuur Hosp, Div Med Virol, Cape Town, South Africa

[22] Univ Cape Town, Ctr Infect Dis Epidemiol & Res, Cape Town, South Africa

[23] Western Cape Govt Hlth, Cape Town, South Africa

[24] Mol Diagnost Serv, Durban, South Africa

[25] Netcare Hosp, Dept Qual Leadership, Johannesburg, South Africa

[26] Univ Free State, NHLS Univ Acad Labs, Div Virol, Bloemfontein, South Africa

[27] NHLS, Port Elizabeth, South Africa

[28] Walter Sisulu Univ, Fac Hlth Sci, Dept Lab Med & Pathol, Mthatha, South Africa

[29] Univ Cape Town, Dept Pathol, Div Med Virol, Cape Town, South Africa

[30] Univ Calif Riverside, Div Biomed Sci, Sch Med, Riverside, CA 92521 USA

[31] Univ Cape Town, Dept Integrat Biomed Sci, Struct Biol Res Unit, Cape Town, South Africa

[32] Univ Oxford, Dept Zool, Oxford, England

[33] Temple Univ, Inst Genom & Evolutionary Med, Philadelphia, PA 19122 USA

[34] Univ Washington, Dept Global Hlth, Seattle, WA 98195 USA

来源：

NATURE | 2021年 / 592卷 / 7854期

基金：

英国医学研究理事会;

关键词：

RECEPTOR-BINDING DOMAIN; MUTATIONS; SITES;

D O I：

10.1038/s41586-021-03402-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Continued uncontrolled transmission of SARS-CoV-2 in many parts of the world is creating conditions for substantial evolutionary changes to the virus(1,2). Here we describe a newly arisen lineage of SARS-CoV-2 (designated 501Y.V2; also known as B.1.351 or 20H) that is defined by eight mutations in the spike protein, including three substitutions (K417N, E484K and N501Y) at residues in its receptor-binding domain that may have functional importance(3-5). This lineage was identified in South Africa after the first wave of the epidemic in a severely affected metropolitan area (Nelson Mandela Bay) that is located on the coast of the Eastern Cape province. This lineage spread rapidly, and became dominant in Eastern Cape, Western Cape and KwaZuluNatal provinces within weeks. Although the full import of the mutations is yet to be determined, the genomic data-which show rapid expansion and displacement of other lineages in several regions-suggest that this lineage is associated with a selection advantage that most plausibly results from increased transmissibility or immune escape(6-8).

引用

页码：438 / +

页数：22

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