Total synthesis of Eudistomins Y1-Y6

被引：14

作者：

Kennedy, J. Phillip ^{[1
,2
]}

Breininger, Micah L. ^{[2
,3
,4
,5
]}

Lindsley, Craig W. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Vanderbilt Univ, Dept Chem, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Med Ctr, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Dept Pharmacol, Nashville, TN 37232 USA

[4] Vanderbilt Univ, Vanderbilt Program Drug Discovery, Nashville, TN 37232 USA

[5] Vanderbilt Univ, Vanderbilt Specialized Chem Ctr Accelerated Probe, Nashville, TN 37232 USA

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 50期

关键词：

BETA-CARBOLINE ALKALOIDS; PRODUCT-GUIDED SYNTHESIS; BIOLOGICAL EVALUATION; UNNATURAL ANALOGS; SEMPERVIRINE; OLIVACEUM; GLAUCUS; FASCAPLYSIN; INHIBITORS; DISPYRIN;

D O I：

10.1016/j.tetlet.2009.09.180

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of Eudistomins Y-1-Y-6, brominated phenolic beta-carboline marine metabolites with a unique benzoyl moiety at C1, have been prepared in three steps, utilizing MAOS, in overall yields ranging from 6% to 25%. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：7067 / 7069

页数：3

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