The synthesis of 1,2,4-benzotriazines

被引：4
作者：
Ziarani, Ghodsi Mohammadi [1 ]
Mostofi, Madine [1 ]
Gholamzadeh, Parisa [1 ]
Mohammadi-Khanaposhtani, Maryam [2 ]
Yavari, Hossein [3 ,4 ]
机构：
[1] Alzahra Univ, Dept Chem, Vanak Sq,POB 1993893973, Tehran, Iran
[2] Babol Univ Med Sci, Cellular & Mol Biol Res Ctr, Hlth Res Inst, POB 4717647745, Babol Sar, Iran
[3] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, POB 14176, Tehran, Iran
[4] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, POB 14176, Tehran, Iran
来源：
ARKIVOC | 2019年
关键词：
1,2,4-Benzotriazines; 1,2,4-benzotriazine N-oxides; 1,2,4-benzotriazine 1,4-dioxides; 3-amino-1,2,4-benzotriazine N-oxides; BENZOTRIAZINE BASED COMPOUNDS; CROSS-COUPLING REACTIONS; 1,2,4-TRIAZINE DERIVATIVES; ANTITUMOR-ACTIVITY; RING CONTRACTION; 1,4-DIOXIDES; ACID; TIRAPAZAMINE; CYCLIZATION; AGENT;
D O I：
10.24820/ark.5550190.p010.791
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The 1,2,4-benzotriazine nucleus fused to a benzene ring is a prominent heterocyclic substructure present in numerous pharmacologically active compounds. To date, many 1,2,4-benzotriazine analogues possessing a wide spectrum of potent pharmacological activities are known. This review compiles information on the synthesis, chemical reactions, medicinal chemistry aspects and applications of 1,2,4-benzotriazines. [GRAPHICS] .
引用
收藏
页码：41 / 105
页数：65
相关论文
共 143 条
  • [81] 1,3-Diphenylbenzo[e][1,2,4]triazin-7(1H)-one: Selected Chemistry at the C-6, C-7 and C-8 Positions
    Koutentis, Panayiotis A.
    Krassos, Harry
    Lo Re, Daniele
    [J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2011, 9 (14) : 5228 - 5237
  • [82] Kumar A., 2009, SYNTHESIS-STUTTGART, V2009, P1663, DOI [10.1055/s-0028-1088055, DOI 10.1055/S-0028-1088055]
  • [83] Synthesis, Preferentially Hypoxic Apoptosis and Anti-Angiogenic Activity of 3-Amino-1,2,4-Benzotriazine-1,4-Dioxide Bearing Alkyl Linkers with a 3-Amino-1,2,4-Benzotriazine-1-Oxide Moiety
    Lee, Chun-I
    Huang, Chien-Ming
    Huang, Wen-Hsin
    Lee, An-Rong
    [J]. ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, 2014, 14 (10) : 1428 - 1446
  • [84] Synthesis and Evaluation of Lipophilic BTBP Ligands for An/Ln Separation in Nuclear Waste Treatment: The Effect of Alkyl Substitution on Extraction Properties and Implications for Ligand Design
    Lewis, Frank W.
    Harwood, Laurence M.
    Hudson, Michael J.
    Distler, Petr
    John, Jan
    Stamberg, Karel
    Nunez, Ana
    Galan, Hitos
    Espartero, Amparo G.
    [J]. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2012, 2012 (08) : 1509 - 1519
  • [85] Ureidobenzotriazine multiple H-bonding arrays: The importance of geometrical details on the stability of H-bonds
    Ligthart, G. B. W. L.
    Guo, Dawei
    Spek, A. L.
    Kooijman, Huub
    Zuilhof, Han
    Sijbesma, Rint P.
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2008, 73 (01) : 111 - 117
  • [86] Lindsley C. W, 2004, SCI SYNTHESIS, V17, P357, DOI [DOI 10.1055/SOS-SD-017-00553, 10.1055/sos-SD-017-00553]
  • [87] Synthesis and tautomeric transformations of 2-(tert-butyl)-1,2,4-benzotriazine-3(2H)-thiones
    Lipilin, D. L.
    Tyurin, A. Yu.
    Smirnov, O. Yu.
    Churakov, A. M.
    Strelenko, Yu. A.
    Tartakovsky, V. A.
    [J]. RUSSIAN CHEMICAL BULLETIN, 2006, 55 (07) : 1239 - 1242
  • [88] Liu Jing-bao, 2009, Yaoxue Xuebao, V44, P695
  • [89] LLOYD RV, 1991, MOL PHARMACOL, V40, P440
  • [90] Hydrazonoyl halides in heterocycles: synthesis and anti-microbial activity of new 1,2,4-benzotriazine and bis-1,2,4-benzotriazine derivatives
    Mahran, Asma M.
    Farghaly, Thoraya A.
    Nada, Afaf A.
    [J]. RESEARCH ON CHEMICAL INTERMEDIATES, 2015, 41 (05) : 2961 - 2969
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