The synthesis of 1,2,4-benzotriazines

被引：4
作者：
Ziarani, Ghodsi Mohammadi [1 ]
Mostofi, Madine [1 ]
Gholamzadeh, Parisa [1 ]
Mohammadi-Khanaposhtani, Maryam [2 ]
Yavari, Hossein [3 ,4 ]
机构：
[1] Alzahra Univ, Dept Chem, Vanak Sq,POB 1993893973, Tehran, Iran
[2] Babol Univ Med Sci, Cellular & Mol Biol Res Ctr, Hlth Res Inst, POB 4717647745, Babol Sar, Iran
[3] Univ Tehran Med Sci, Fac Pharm, Dept Med Chem, POB 14176, Tehran, Iran
[4] Univ Tehran Med Sci, Pharmaceut Sci Res Ctr, POB 14176, Tehran, Iran
来源：
ARKIVOC | 2019年
关键词：
1,2,4-Benzotriazines; 1,2,4-benzotriazine N-oxides; 1,2,4-benzotriazine 1,4-dioxides; 3-amino-1,2,4-benzotriazine N-oxides; BENZOTRIAZINE BASED COMPOUNDS; CROSS-COUPLING REACTIONS; 1,2,4-TRIAZINE DERIVATIVES; ANTITUMOR-ACTIVITY; RING CONTRACTION; 1,4-DIOXIDES; ACID; TIRAPAZAMINE; CYCLIZATION; AGENT;
D O I：
10.24820/ark.5550190.p010.791
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The 1,2,4-benzotriazine nucleus fused to a benzene ring is a prominent heterocyclic substructure present in numerous pharmacologically active compounds. To date, many 1,2,4-benzotriazine analogues possessing a wide spectrum of potent pharmacological activities are known. This review compiles information on the synthesis, chemical reactions, medicinal chemistry aspects and applications of 1,2,4-benzotriazines. [GRAPHICS] .
引用
收藏
页码：41 / 105
页数：65
相关论文
共 143 条
  • [71] Synthesis and hypoxic-cytotoxic activity of some 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives
    Jiang, Faqin
    Yang, Bo
    Fan, Lingling
    He, Qiaojun
    Hu, Yongzhou
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2006, 16 (16) : 4209 - 4213
  • [72] SYNTHESES IN THE 1,2,4-BENZOTRIAZINE SERIES
    JIU, J
    MUELLER, GP
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 1959, 24 (06) : 813 - 818
  • [73] Crystal structures of 3-methyl-1,2,4-benzotriazine 1-oxide and 2-oxide
    Junnotula, Venkatraman
    Sarkar, Ujjal
    Barnes, Charles L.
    Thallapally, Praveen K.
    Gates, Kent S.
    [J]. JOURNAL OF CHEMICAL CRYSTALLOGRAPHY, 2006, 36 (09) : 557 - 561
  • [74] The Planar Blatter Radical: Structural Chemistry of 1,4-Dihydrobenzo[e][1,2,4]triazin-4-yls
    Kaszynski, Piotr
    Constantinides, Christos P.
    Young, Victor G., Jr.
    [J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 55 (37) : 11149 - 11152
  • [75] Anti-Cancer Activity of Phenyl and Pyrid-2-yl 1,3-Substituted Benzo[1,2,4]triazin-7-ones and Stable Free Radical Precursors
    Keane, Lee-Ann J.
    Mirallai, Styliana I.
    Sweeney, Martin
    Carty, Michael P.
    Zissimou, Georgia A.
    Berezin, Andrey A.
    Koutentis, Panayiotis A.
    Aldabbagh, Fawaz
    [J]. MOLECULES, 2018, 23 (03):
  • [76] Kelson AB, 1998, ANTI-CANCER DRUG DES, V13, P575
  • [77] Two-step syntheses of 3-methyl and 3-phenyl-1,2,4-benzotriazines
    Khodja, M
    Moulay, S
    Boutoumi, H
    Wilde, H
    [J]. HETEROATOM CHEMISTRY, 2006, 17 (02) : 166 - 172
  • [78] Kotovskaya SK, 2007, PHARM CHEM J, V41, P62, DOI [DOI 10.1007/s11094-007-0014-5, 10.1007/s11094-007-0014-5, DOI 10.1007/S11094-007-0014-5]
  • [79] Koutentis P. A., 2010, SYNTHESIS-STUTTGART, V2010, P2075
  • [80] Synthesis of Triazafluoranthenones via Silver(I)-Mediated Nonoxidative and Oxidative Intramolecular Palladium-Catalyzed Cyclizations
    Koutentis, Panayiotis A.
    Loizou, Georgia
    Lo Re, Daniele
    [J]. JOURNAL OF ORGANIC CHEMISTRY, 2011, 76 (14) : 5793 - 5802
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