Role of microbes, metabolites and effector compounds in host-microbiota interaction: a pharmacological outlook

被引：20

作者：

Bhushan, Bharat ^{[1
]}

Singh, Brij Pal ^{[2
]}

Saini, Kamna ^{[3
]}

Kumari, Mamta ^{[1
]}

Tomar, Sudhir Kumar ^{[3
]}

Mishra, Vijendra ^{[1
]}

机构：

[1] Natl Inst Food Technol Entrepreneurship & Managem, Sonipat 131028, Haryana, India

[2] RK Univ, Rajkot 360020, Gujarat, India

[3] ICAR Natl Dairy Res Inst, Karnal 132001, Haryana, India

来源：

ENVIRONMENTAL CHEMISTRY LETTERS | 2019年 / 17卷 / 04期

关键词：

Microbiota; Probiotics; Metabolites; Effector molecules; Pharmacology; Drug metabolism; CHAIN FATTY-ACIDS; BIFIDOBACTERIUM-BIFIDUM G9-1; LACTOBACILLUS-GASSERI KS-13; BUTYRATE-PRODUCING BACTERIA; ENTEROCOCCUS-MUNDTII ST4SA; GUT MICROBIOTA; INTESTINAL MICROBIOTA; DOUBLE-BLIND; WIDE ASSOCIATION; FERMENTED MILK;

D O I：

10.1007/s10311-019-00914-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Microbial cells react with intestinal surfaces and produce enzymes and metabolites that influence human health, host metabolism and immunity. Gut microbiota and probiotics also influence host physiology. Here, we review 1) the role of host-microbiota composition and microbial enzymes in human well-being and in human metabolism for the degradation of indigestible dietary components; 2) the effects of gut microbiota on drug metabolism; 3) the roles of probiotic composition, metabolites, e.g. vitamins, bacteriocins, acids and bioactive peptides, and effector compounds, e.g. polysaccharides, outer membrane proteins, pili, muropeptides and CpG-rich DNA, for clinical outcomes; and 4) a new perspective of microbial global positioning system (mGPS) for segregation of human disease phenotypes on the basis of their microbiota.

引用

页码：1801 / 1820

页数：20

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