Widening the usefulness of epoxides and aziridines in synthesis

被引：56

作者：

Hodgson, David M. ^{[1
]}

Humphreys, Philip G. ^{[1
]}

Hughes, Steven R. ^{[1
]}

机构：

[1] Univ Oxford, Chem Res Lab, Dept Chem, Oxford OX1 3TA, England

来源：

PURE AND APPLIED CHEMISTRY | 2007年 / 79卷 / 02期

关键词：

asymmetric synthesis; aziridines; carbenoids; epoxides; lithiation;

D O I：

10.1351/pac200779020269

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Deprotonation of terminal epoxides and aziridines with organolithium/diamine combinations or lithium amides allows the regio- and stereoselective formation of alpha-lithiated species. Judicious choice of reaction conditions allows these species to operate as nucleophiles, enolate equivalents, vinyl cation equivalents, or carbenes.

引用

页码：269 / 279

页数：11

共 20 条

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