Association between Cytokine Gene Polymorphisms and Breast Cancer in Postmenopausal Women

被引：3
作者：
Gordeeva, L. A. [1 ]
Mun, S. A. [1 ]
Voronina, E. N. [2 ]
Polenok, E. G. [1 ]
Sokolova, E. A. [2 ]
Verzhbitskaya, N. E. [3 ]
Antonov, A., V [3 ]
Lutsenko, V. A. [3 ]
Filipenko, M. L. [2 ]
Glushkov, A. N. [1 ]
机构：
[1] Russian Acad Sci, Fed Res Ctr Coal & Coal Chem, Inst Human Ecol, Siberian Branch, Kemerovo 650065, Russia
[2] Russian Acad Sci, Inst Chem Biol & Fundamental Med, Siberian Branch, Novosibirsk 630090, Russia
[3] Reg Clin Oncol Dispensary, Kemerovo 650036, Russia
来源：
ADVANCES IN GERONTOLOGY | 2021年 / 11卷 / 01期
关键词：
breast cancer; postmenopause; cytokine genes; INTERLEUKIN-6; INFLAMMATION; RISK; IMMUNITY; DISEASE; IL6;
D O I：
10.1134/S2079057021010367
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The goal of this study was to investigate the association between the polymorphic loci of genes IL1B (rs16944), IL1RN (rs4251961), IL6 (rs1800795, rs1800796, rs1554606), IL8 (rs4073), IL10 (rs1800896), and TNFA (rs1800629) and breast cancer in women. The DNA samples of 521 women with breast cancer and 267 women without oncological pathology were studied. The study showed that age, concomitant chronic morbidity, and polymorphism of the IL6 gene are risk factors in postmenopausal women. Allele -572C (OR = 5.68; 95% CI = [2.70-11.97], p(cor) < 0.001), and haplotype rs1800796[C]-rs1800795[G]-rs1554606[G] (OR = 5.31, 95% CI = [1.87 - 15.10], p(cor) = 0.002) of the IL6 gene were associated with breast cancer. No association of loci in IL1B (rs16944), IL1RN (rs4251961), IL8 (rs4073), IL10 (rs1800896), or TNFA (rs1800629) was associated with the risk of breast cancer. The obtained data indicate that the -572C allele of the IL6 gene is associated with susceptibility in postmenopausal women to breast cancer. Our results can be useful for an understanding of the molecular mechanisms of breast cancer.
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页码：44 / 52
页数：9
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