Recent Progress in the Synthesis of Naturally Occurring Triterpenoid Saponins

被引：37
作者：
Gauthier, Charles [1 ]
Legault, Jean [1 ]
Pichette, Andre [1 ]
机构：
[1] Univ Quebec Chicoutimi, Lab LASEVE, Chaire Rech Agents Anticancereux Origine Nat, Dept Sci Fondamentales, Chicoutimi, PQ G7H 2B1, Canada
来源：
MINI-REVIEWS IN ORGANIC CHEMISTRY | 2009年 / 6卷 / 04期
关键词：
Natural products; Saponins; Triterpenes; Chemical synthesis; Cytotoxic; Anticancer; C-13; NMR-SPECTROSCOPY; PANACIS-JAPONICI RHIZOMA; OLEANOLIC ACID SAPONINS; LUPANE-TYPE SAPONINS; SURINAM RAIN-FOREST; BETULINIC ACID; PULSATILLA-CHINENSIS; ANTITUMOR-ACTIVITY; ALPHA-HEDERIN; IN-VITRO;
D O I：
10.2174/157019309789371541
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
This short review describes the recently reported semi- and total syntheses of naturally occurring triterpenoid saponins. Accent is placed on natural monodesmosidic and bidesmosidic saponins of the oleanane- and lupane-type that possess potent pharmacological properties including cytotoxic and antitumor activities.
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收藏
页码：321 / 344
页数：24
相关论文
共 135 条
[1]   Two bioactive saponins from Albizia subdimidiata from the Suriname rainforest [J].
Abdel-Kader, M ;
Hoch, J ;
Berger, JM ;
Evans, R ;
Miller, JS ;
Wisse, JH ;
Mamber, SW ;
Dalton, JM ;
Kingston, DGI .
JOURNAL OF NATURAL PRODUCTS, 2001, 64 (04) :536-539
[2]   C-13 NMR-SPECTROSCOPY OF OLEANANE TRITERPENOIDS [J].
AGRAWAL, PK ;
JAIN, DC .
PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY, 1992, 24 :1-90
[3]  
Agrawal PK, 1996, PHYTOCHEM ANALYSIS, V7, P113, DOI 10.1002/(SICI)1099-1565(199605)7:3<113::AID-PCA300>3.0.CO
[4]  
2-L
[5]   C-13 NMR SPECTRAL INVESTIGATIONS .10. C-13 NMR-SPECTROSCOPY OF STEROIDAL SAPOGENINS AND STEROIDAL SAPONINS [J].
AGRAWAL, PK ;
JAIN, DC ;
GUPTA, RK ;
THAKUR, RS .
PHYTOCHEMISTRY, 1985, 24 (11) :2479-2496
[6]   Pharmacological properties of the ubiquitous natural product betulin [J].
Alakurtti, Sami ;
Makela, Taru ;
Koskimies, Salme ;
Yli-Kauhaluoma, J. .
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2006, 29 (01) :1-13
[7]   TRITERPENOID SAPONINS FROM FATSIA-JAPONICA [J].
AOKI, T ;
TANIO, Y ;
SUGA, T .
PHYTOCHEMISTRY, 1976, 15 (05) :781-784
[8]   SEMISYNTHETIC ANALOGS OF GINSENOSIDES, GLYCOSIDES FROM GINSENG [J].
ATOPKINA, LN ;
DENISENKO, VA ;
UVAROVA, NI ;
ELYAKOV, GB .
CARBOHYDRATE RESEARCH, 1988, 177 :101-109
[9]   Cytotoxicity of natural ginseng glycosides and semisynthetic analogues [J].
Atopkina, LN ;
Malinovskaya, GV ;
Elyakov, GB ;
Uvarova, NI ;
Woerdenbag, HJ ;
Koulman, A ;
Potier, P .
PLANTA MEDICA, 1999, 65 (01) :30-34
[10]   Saponins in tumor therapy [J].
Bachran, Christopher ;
Bachran, Silke ;
Sutherland, Mark ;
Bachran, Diana ;
Fuchs, Hendrik .
MINI-REVIEWS IN MEDICINAL CHEMISTRY, 2008, 8 (06) :575-584
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