Dual self-assembly of supramolecular peptide nanotubes to provide stabilisation in water

被引：69

作者：

Rho, Julia Y. ^{[1
]}

Cox, Henry ^{[2
]}

Mansfield, Edward D. H. ^{[1
]}

Ellacott, Sean H. ^{[1
]}

Peltier, Raoul ^{[1
]}

Brendel, Johannes C. ^{[1
]}

Hartlieb, Matthias ^{[1
]}

Waigh, Thomas A. ^{[2
,3
]}

Perrier, Sebastien ^{[1
,4
,5
]}

机构：

[1] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

[2] Univ Manchester, Sch Phys & Astron, Biol Phys, Manchester M13 9PL, Lancs, England

[3] Univ Manchester, Photon Sci Inst, Manchester M13 9PL, Lancs, England

[4] Monash Univ, Fac Pharm & Pharmaceut Sci, Parkville, Vic 3052, Australia

[5] Univ Warwick, Warwick Med Sch, Coventry CV4 7AL, W Midlands, England

来源：

NATURE COMMUNICATIONS | 2019年 / 10卷 / 1期

基金：

欧洲研究理事会; 英国工程与自然科学研究理事会;

关键词：

FRAGMENTATION CHAIN TRANSFER; CO-MICELLES; POLYMER; MINERALIZATION; HYDROGELS; SYSTEMS; GROWTH; LENGTH;

D O I：

10.1038/s41467-019-12586-8

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Self-assembling peptides have the ability to spontaneously aggregate into large ordered structures. The reversibility of the peptide hydrogen bonded supramolecular assembly make them tunable to a host of different applications, although it leaves them highly dynamic and prone to disassembly at the low concentration needed for biological applications. Here we demonstrate that a secondary hydrophobic interaction, near the peptide core, can stabilise the highly dynamic peptide bonds, without losing the vital solubility of the systems in aqueous conditions. This hierarchical self-assembly process can be used to stabilise a range of different beta-sheet hydrogen bonded architectures.

引用

页数：9

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