Potential Antioxidative, Anti-inflammatory and Immunomodulatory Effects of Ghrelin, an Endogenous Peptide from the Stomach in SARS-CoV2 Infection

被引：15

作者：

Jafari, Abbas ^{[1
,2
]}

Sadeghpour, Sonia ^{[3
]}

Ghasemnejad-Berenji, Hojat ^{[4
]}

Pashapour, Sarvin ^{[5
]}

Ghasemnejad-Berenji, Morteza ^{[6
,7
]}

机构：

[1] Urmia Univ Med Sci, Fac Hlth, Dept Toxicol, Orumiyeh, Iran

[2] Urmia Univ Med Sci, Fac Hlth, Neurophysiol Res Ctr, Orumiyeh, Iran

[3] Urmia Univ Med Sci, Sch Med, Dept Obstet & Gynecol, Orumiyeh, Iran

[4] Shahid Beheshti Univ Med Sci, Sch Med, Dept Anat & Reprod Biol, Tehran, Iran

[5] Urmia Univ Med Sci, Sch Med, Dept Pediat, Orumiyeh, Iran

[6] Urmia Univ Med Sci, Sch Pharm, Dept Pharmacol & Toxicol, POB 5715799313, Orumiyeh, Iran

[7] Urmia Univ Med Sci, Res Ctr Expt & Appl Pharmaceut Sci, Orumiyeh, Iran

来源：

INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS | 2021年 / 27卷 / 03期

关键词：

COVID-19; Ghrelin; Oxidative stress; Inflammation; NF-kappa B; SARS-CoV-2; PPAR gamma;

D O I：

10.1007/s10989-021-10217-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The current COVID-19 pandemic is one of the most devastating events in recent history. The respiratory effects of this disease include acute respiratory distress syndrome, systemic inflammation, cytokine storm, and pulmonary fibrosis. Ghrelin, an endogenous ligand for the growth hormone secretagogue receptor, is a peptide hormone secreted mainly by the stomach. Interestingly, ghrelin possesses promising antioxidant, anti-and inflammatory effects, making it an attractive agent to reduce the complications of the SARS-CoV-2. In addition, ghrelin exerts a wide range of immunomodulatory and anti-inflammatory effects and can mitigate the uncontrolled cytokine production responsible for acute lung injury by upregulating PPAR gamma and down-regulating NF-kappa B expression. Ghrelin has also been reported to enhance Nrf2 expression in inflammatory conditions which led to the suppression of oxidative stress. The current opinion summarizes the evidence for the possible pharmacological benefits of ghrelin in the therapeutic management of SARS-CoV-2 infection.

引用

页码：1875 / 1883

页数：9

共 102 条

[31] Could SARS-CoV-2-Induced Hyperinflammation Magnify the Severity of Coronavirus Disease (CoViD-19) Leading to Acute Respiratory Distress Syndrome? [J].