Gold-Catalyzed Tandem Cycloisomerization-Halogenation of Chiral Homopropargyl Sulfonamides

被引：22

作者：

Shu, Chao ^{[1
,2
]}

Li, Long ^{[1
,2
]}

Shen, Cang-Hai ^{[1
,2
]}

Ruan, Peng-Peng ^{[1
,2
]}

Liu, Chao-Yue ^{[1
,2
]}

Ye, Long-Wu ^{[1
,2
,3
]}

机构：

[1] Xiamen Univ, Coll Chem & Chem Engn, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Fujian, Peoples R China

[2] Xiamen Univ, Coll Chem & Chem Engn, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Fujian, Peoples R China

[3] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2016年 / 22卷 / 07期

基金：

中国国家自然科学基金;

关键词：

cycloisomerization; gold; halogenation; heterocycles; homogeneous catalysis; EFFICIENT SYNTHESIS; INTERMOLECULAR OXIDATION; REGIOSELECTIVE SYNTHESIS; TERT-BUTANESULFINAMIDE; ASYMMETRIC-SYNTHESIS; ORGANOGOLD COMPOUNDS; PRACTICAL SYNTHESIS; PROPARGYLIC AMIDES; ALKYNES; DERIVATIVES;

D O I：

10.1002/chem.201503891

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Two new gold-catalyzed tandem cycloisomerization-halogenation reactions of chiral homopropargyl sulfonamides have been developed. Various enantioenriched 3,3-diiodopyrrolidin-2-ols and 3-fluoropyrrolidin-2-ols were obtained in moderate-to-good yields with excellent enantio- and diastereoselectivity.

引用

页码：2282 / 2290

页数：9

共 87 条

[21] Transition Metal-Mediated Synthesis of Monocyclic Aromatic Heterocycles [J].