A CONCISE SYNTHESIS OF SOLAMIN AND CIS-SOLAMIN, MONO-THF ACETOGENINS FROM ANNONA MURICATA

被引：8
作者：
Makabe, Hidefumi [1 ,2 ]
Kuwabara, Asuka [1 ]
Hattori, Yasunao [2 ,3 ]
Konno, Hiroyuki [4 ]
机构：
[1] Shinshu Univ, Grad Sch Agr, Nagano 3994598, Japan
[2] Shinshu Univ, Interdisciplinary Grad Sch Sci & Technol, Nagano 3994598, Japan
[3] Shinshu Univ, Satellite Venture Business Lab, Nagano 3868567, Japan
[4] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Chem, Kyoto 6038334, Japan
来源：
HETEROCYCLES | 2009年 / 78卷 / 09期
关键词：
Acetogenin; Antitumor; Asymmetric Synthesis; Polyketide; THF Ring; MITOCHONDRIAL COMPLEX-I; INHIBITORY-ACTION; OXIDATIVE CYCLIZATION; PYRANICIN; DIASTEREOMERS; RETICULATACIN; ANALOGS;
D O I：
10.3987/COM-09-11741
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A concise total synthesis of solamin (1) and cis-solamin (2) was performed using an epoxy alcohol (11) as a versatile chiral building block for synthesizing the stereoisomers of the mono-THF annonaceous acetogenins.
引用
收藏
页码：2369 / 2376
页数：8
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