Interfacing the Cell with "Biomimetic Membrane Proteins"

被引：7
作者：
Grupi, Asaf [1 ,2 ]
Ashur, Idan [3 ]
Degani-Katzav, Nurit [1 ,2 ]
Yudovich, Shimon [1 ,2 ]
Shapira, Zehavit [1 ,2 ]
Marzouq, Adan [1 ,2 ]
Morgenstein, Lion [1 ,2 ]
Mandel, Yossi [2 ,4 ]
Weiss, Shimon [1 ,2 ,5 ,6 ]
机构：
[1] Bar Ilan Univ, Inst Nanotechnol & Adv Mat, Dept Phys, IL-5290002 Ramat Gan, Israel
[2] Bar Ilan Univ, Inst Nanotechnol & Adv Mat, IL-5290002 Ramat Gan, Israel
[3] Inst Agr Engn, Volcani Ctr, Agr Res Org, IL-7505101 Rishon Leziyyon, Israel
[4] Bar Ilan Univ, Fac Life Sci, Sch Optometry & Vis Sci, IL-5290002 Ramat Gan, Israel
[5] Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
[6] Univ Calif Los Angeles, Calif NanoSyst Inst, Los Angeles, CA 90095 USA
来源：
SMALL | 2019年 / 15卷 / 52期
基金：
欧洲研究理事会; 美国国家科学基金会;
关键词：
biomimetic membrane proteins; membrane proteins; nanoparticles insertion into membranes; nanorods; quantum dots; LIGAND-COATED NANOPARTICLES; SPANNING DNA NANOPORES; GOLD NANOPARTICLES; LIPID-BILAYERS; QUANTUM-DOT; SEMICONDUCTOR NANOPARTICLES; COMPUTER-SIMULATION; TATA COMPONENT; GANGLION-CELLS; CHAIN-LENGTH;
D O I：
10.1002/smll.201903006
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Integral membrane proteins mediate a myriad of cellular processes and are the target of many therapeutic drugs. Enhancement and extension of the functional scope of membrane proteins can be realized by membrane incorporation of engineered nanoparticles designed for specific diagnostic and therapeutic applications. In contrast to hydrophobic insertion of small amphiphilic molecules, delivery and membrane incorporation of particles on the nanometric scale poses a crucial barrier for technological development. In this perspective, the transformative potential of biomimetic membrane proteins (BMPs), current state of the art, and the barriers that need to be overcome in order to advance the field are discussed.
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页数：11
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