ent-Atisane diterpenoids from Euphorbia fischeriana inhibit mammosphere formation in MCF-7 cells

被引：30
|
作者：
Kuang, Xinzhu [1 ]
Li, Wei [1 ]
Kanno, Yuichiro [1 ]
Yamashita, Naoya [1 ]
Nemoto, Kiyomitsu [1 ]
Asada, Yoshihisa [2 ]
Koike, Kazuo [1 ]
机构：
[1] Toho Univ, Fac Pharmaceut Sci, Miyama 2-2-1, Funabashi, Chiba 2748510, Japan
[2] Tokyo Univ Sci, Fac Pharmaceut Sci, 2641 Yamazaki, Noda, Chiba 2788510, Japan
来源：
JOURNAL OF NATURAL MEDICINES | 2016年 / 70卷 / 01期
关键词：
Euphorbia fischeriana; Euphorbiaceae; Cancer stem cells; ent-Atisane; Diterpenoid; Mammosphere formation; CANCER STEM-CELLS; ROOTS; FIDJIANA;
D O I：
10.1007/s11418-015-0940-6
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The discovery of new drugs that target cancer stem cells (CSCs) is a critical approach to overcome the major difficulties of the metastasis, chemotherapeutic resistance and recurrence for successful cancer therapy. Chemical investigation of the roots of Euphorbia fischeriana resulted in the isolation of eight ent-atisane diterpenoids (1-8), including two new compounds: 19-O-beta-D-glucopyranosyl-ent-atis-16-ene-3,14-dione (7) and 19-O-(6-galloyl)-beta-D-glucopyranosyl-ent-atis-16-ene-3,14-dione (8). The structures were elucidated on extensive spectroscopic analyses, as well as chemical transformations. ent-3 beta-Hydroxyatis-16-ene-2,14-dione (5), 7 and its aglycon, ent-19-hydroxy-atis-16-ene-3,14-dione (7a), showed significant inhibitory activity on mammosphere formation in human breast cancer MCF-7 cells at a final concentration of 10 mu M.
引用
收藏
页码：120 / 126
页数：7
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