Effect of Triterpene Acids of Eriobotrya japonica (Thunb.) Lindl. Leaf and MAPK Signal Transduction Pathway on Inducible Nitric Oxide Synthase Expression in Alveolar Macrophage of Chronic Bronchitis Rats

被引：21

作者：

Huang, Y. ^{[1
]}

Li, J. ^{[1
]}

Meng, X. M. ^{[1
]}

Jiang, G. L. ^{[1
]}

Li, H. ^{[1
]}

Cao, Q. ^{[1
]}

Yu, S. C. ^{[2
]}

Lv, X. W. ^{[1
]}

Cheng, W. M. ^{[1
]}

机构：

[1] Anhui Med Univ, Sch Pharm, Hefei 230032, Anhui, Peoples R China

[2] Anhui An Tai Med Co, Hefei 230032, Anhui, Peoples R China

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 2009年 / 37卷 / 06期

关键词：

Chronic Bronchitis (CB); Alveolar Macrophage (AM); Inducible Nitric Oxide Synthase (iNOS); Nitric Oxide (NO); MAPK Signal Transduction; NF-KAPPA-B; INOS EXPRESSION; INFLAMMATION; INHIBITION; ACTIVATION; KINASES; CELLS; MODEL; LPS;

D O I：

10.1142/S0192415X09007521

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

The goal of this study was to investigate the possible therapy mechanism of triterpene acids of Eriobotrya japonica (Thunb.) Lindl. Leaf (TAL) in alveolar macrophage (AM) of chronic bronchitis (CB) rats. CB model was established by injection of bacillus calmette guein (BCG) plus lipopolisacharide (LPS) in rats. TAL significantly inhibited the increased NO concentration, iNOS expression and phosphorylation of p38 MAPK in alveolar macrophages (AMs) of CB rats. Using in vivo test, we found that SB203580, a p38 MAPK inhibitor, (10 mu M) significantly inhibited inducible nitric oxide synthase (iNOS) mRNA expression in AM. This data indicate that TAL highly decreases excessive iNOS expression and NO induction, and p38 MAPK signal transduction participates in iNOS expression and NO induction in AM of CB rats. The effect of TAL on iNOS expression in AM may be related to its inhibition of p38 MAPK signal transduction.

引用

页码：1099 / 1111

页数：13

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