Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots

被引：117
作者：
Prinzen, Lenneke
Miserus, Robbert-Jan J. H. M.
Dirksen, Anouk
Hackeng, Tilman M.
Deckers, Niko
Bitsch, Nicole J.
Megens, Remco T. A.
Douma, Kim
Heemskerk, Johan W.
Kooi, M. Eline
Frederik, Peter M.
Slaaf, Dick W.
van Zandvoort, Marc A. M. J.
Reutelingsperger, Chris P. M.
机构：
[1] Univ Maastricht, Dept Biophys, NL-6200 MD Maastricht, Netherlands
[2] Univ Hosp Maastricht, Dept Biochem, NL-6200 MD Maastricht, Netherlands
[3] Univ Maastricht, Dept Cardiol, NL-6200 MD Maastricht, Netherlands
[4] Univ Maastricht, Electron Microscopy Unit, Dept Pathol, NL-6200 MD Maastricht, Netherlands
[5] Tech Univ Eindhoven, Dept Biomed Engn, Eindhoven, Netherlands
来源：
NANO LETTERS | 2007年 / 7卷 / 01期
关键词：
D O I：
10.1021/nl062226r
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A quantum-dot-based nanoparticle is presented, allowing visualization of cell death and activated platelets with fluorescence imaging and MRI. The particle exhibits intense fluorescence and a large MR relaxivity (r(1)) of 3000-4500 mM(-1) s(-1) per nanoparticle due to a newly designed construct increasing the gadolinium-DTPA load. The nanoparticle is suitable for both anatomic and subcellular imaging of structures in the vessel wall and is a promising bimodal contrast agent for future in vivo imaging studies.
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收藏
页码：93 / 100
页数：8
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