Hemorrhagic regression of melanoma metastases during therapeutic vaccination: a report of three cases

被引：3

作者：

Pierret, Lauranne ^{[2
]}

Van Baren, Nicolas ^{[6
]}

Bonehill, Aude ^{[7
]}

Corthals, Jurgen ^{[7
]}

Van Nuffel, An M. T. ^{[7
]}

Heirman, Carlo ^{[7
]}

Roelandt, Truus ^{[2
]}

De Coninck, Arlette ^{[2
]}

Van Riet, Ivan ^{[5
]}

Degreef, Ellen ^{[3
]}

Goossens, Annieta ^{[3
]}

Verfaillie, Guy ^{[4
]}

Roseeuw, Diane ^{[2
]}

Thielemans, Kris ^{[7
]}

Neyns, Bart ^{[1
]}

机构：

[1] UZ Brussel, Ctr Oncol, Dept Med Oncol, B-1090 Brussels, Belgium

[2] UZ Brussel, Dept Dermatol, B-1090 Brussels, Belgium

[3] UZ Brussel, Dept Pathol, B-1090 Brussels, Belgium

[4] UZ Brussel, Dept Surg, B-1090 Brussels, Belgium

[5] UZ Brussel, Dept Stem Cell Lab Clin Hematol, B-1090 Brussels, Belgium

[6] Catholic Univ Louvain, Cellular Genet Unit, Ludwig Inst Canc Res, Christian Duve Inst, Louvain, Belgium

[7] Vrije Univ Brussel, Lab Mol & Cellular Therapy, Brussels, Belgium

来源：

MELANOMA RESEARCH | 2009年 / 19卷 / 06期

关键词：

dendritic cell vaccine; hemorrhagic; melanoma; metastasis; peptide vaccine; MALIGNANT-MELANOMA; CANCER-IMMUNOTHERAPY; CUTANEOUS METASTASIS; BRAIN METASTASES; DENDRITIC CELLS; PATIENT; TUMOR;

D O I：

10.1097/CMR.0b013e32832eabb5

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Melanoma metastases are characterized by pronounced neo-angiogenesis and spontaneous bleeding frequently occurring within central nervous system metastases. Clinically apparent spontaneous hemorrhage within subcutaneous melanoma metastases, however, is a rare event that coincides with progression of such metastases. We report, to our knowledge the first observation, on regression of subcutaneous metastases with hemorrhage of the overlying skin in three patients with stage IV melanoma who participated in clinical trials on therapeutic vaccination. In two patients, loss of arterial flow on Doppler ultrasound imaging was documented in the metastasis at the time of hematoma formation. One patient suffered from an intracranial hemorrhage in a subcentimetric brain metastasis coincident with the hemorrhagic regression of some of his skin metastases. Melanoma Res 19:385-390 (C) 2009 Wolters Kluwer Health | Lippincott Williams & Wilkins.

引用

页码：385 / 390

页数：6

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