Chemical approaches untangling sequence-specific DNA binding by proteins

被引：1
|
作者：
Sato, S
Hagihara, M
Sugimoto, K
Morii, T
机构：
[1] Institute of Advanced Energy, Kyoto University, Uji
[2] PRESTO, Japan Sci./Technology Corporation, Uji
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2002年 / 8卷 / 22期
关键词：
DNA recognition; host-guest systems; molecular recognition; protein design; peptide design;
D O I：
10.1002/1521-3765(20021115)8:22<5066::AID-CHEM5066>3.0.CO;2-0
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Structure-based design of novel DNA-binding proteins provides an ultimate test of our understanding of protein-DNA interactions. A combination of synthetic, organic, biochemical and molecular biological approaches has been developed to study the principle of molecular recognition associated with the protein -DNA interactions. The strategies enabled a specific formation of noncovalent peptide dimers and determination of the preferential DNA-binding sequence of short peptides.
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页码：5066 / 5071
页数：6
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