Influence of microRNAs and Long Non-Coding RNAs in Cancer Chemoresistance

被引：98

作者：

Ayers, Duncan ^{[1
,2
]}

Vandesompele, Jo ^{[3
,4
]}

机构：

[1] Univ Malta, Ctr Mol Med & Biobanking, MSD-2080 Msida, Malta

[2] Univ Manchester, Fac Biol Med & Hlth, Manchester M1 7DN, Lancs, England

[3] Univ Ghent, Ctr Med Genet Ghent, B-9000 Ghent, Belgium

[4] Univ Ghent, Canc Res Inst Ghent, B-9000 Ghent, Belgium

来源：

GENES | 2017年 / 8卷 / 03期

关键词：

miRNA; lncRNA; cancer; chemoresistance; drug resistance; tumour; microRNA; CELL LUNG-CANCER; HEPATOCELLULAR-CARCINOMA CELLS; CISPLATIN-INDUCED APOPTOSIS; EPITHELIAL-MESENCHYMAL TRANSITION; CONFERS PACLITAXEL RESISTANCE; DNA-DAMAGE RESPONSE; NF-KAPPA-B; OVARIAN-CANCER; BREAST-CANCER; COLORECTAL-CANCER;

D O I：

10.3390/genes8030095

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Innate and acquired chemoresistance exhibited by most tumours exposed to conventional chemotherapeutic agents account for the majority of relapse cases in cancer patients. Such chemoresistance phenotypes are of a multi-factorial nature from multiple key molecular players. The discovery of the RNA interference pathway in 1998 and the widespread gene regulatory influences exerted by microRNAs (miRNAs) and other non-coding RNAs have certainly expanded the level of intricacy present for the development of any single physiological phenotype, including cancer chemoresistance. This review article focuses on the latest research efforts in identifying and validating specific key molecular players from the two main families of non-coding RNAs, namely miRNAs and long non-coding RNAs (lncRNAs), having direct or indirect influences in the development of cancer drug resistance properties and how such knowledge can be utilised for novel theranostics in oncology.

引用

页数：34

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