B7-H1 (PD-L1, CD274) suppresses host immunity in T-cell lymphoproliferative disorders

被引：179

作者：

Wilcox, Ryan A. ^{[1
]}

Feldman, Andrew L. ^{[2
]}

Wada, David A. ^{[3
]}

Yang, Zhi-Zhang ^{[1
]}

Comfere, Nneka I. ^{[3
]}

Dong, Haidong ^{[4
]}

Kwon, Eugene D. ^{[5
]}

Novak, Anne J. ^{[1
]}

Markovic, Svetomir N. ^{[1
]}

Pittelkow, Mark R. ^{[3
]}

Witzig, Thomas E. ^{[1
]}

Ansell, Stephen M. ^{[1
]}

机构：

[1] Mayo Clin, Div Hematol, Rochester, MN 55905 USA

[2] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN 55905 USA

[3] Mayo Clin, Dept Dermatol, Rochester, MN 55905 USA

[4] Mayo Clin, Dept Immunol, Rochester, MN 55905 USA

[5] Mayo Clin, Dept Urol, Rochester, MN 55905 USA

来源：

BLOOD | 2009年 / 114卷 / 10期

基金：

美国国家卫生研究院;

关键词：

ABSOLUTE LYMPHOCYTE COUNT; LEUKOCYTE ANTIGEN-DR; PROGNOSTIC MARKER; TYROSINE KINASE; EXPRESSION; IDENTIFICATION; MONOCYTES; PREDICTS; RECEPTOR; SURVIVAL;

D O I：

10.1182/blood-2009-04-216671

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Stromal elements present within the tumor microenvironment may suppress host immunity and promote the growth of malignant lymphocytes in B cell-derived non-Hodgkin lymphoma (NHL). In contrast, little is known about the microenvironment's role in T cell-derived NHL. B7-H1 (PD-L1, CD274), a member of the B7 family of costimulatory/coinhibitory ligands expressed by both malignant cells and stromal cells within the tumor microenvironment, has emerged as an important immune modulator capable of suppressing host immunity. Therefore, B7-H1 expression and function were analyzed in cutaneous and peripheral T-cell NHL. B7-H1 was expressed by tumor cells, monocytes, and monocyte-derived cells within the tumor microenvironment in T-cell NHL and was found to inhibit T-cell proliferation and promote the induction of FoxP3(+) regulatory T cells. Collectively, the data presented provide the first evidence implicating B7-H1 in the suppression of host immunity in T-cell lymphoproliferative disorders and suggest that the targeting of B7-H1 may represent a novel therapeutic approach. (Blood. 2009; 114: 2149-2158)

引用

页码：2149 / 2158

页数：10

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