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Accumulation of iron in the putamen predicts its shrinkage in healthy older adults: A multi-occasion longitudinal study
被引:60
作者:
Daugherty, Ana M.
[1
]
Raz, Naftali
[1
,2
]
机构:
[1] Wayne State Univ, Inst Gerontol, Detroit, MI 48202 USA
[2] Wayne State Univ, Dept Psychol, 71 W Warren Ave, Detroit, MI 48202 USA
来源:
基金:
美国国家卫生研究院;
关键词:
Aging;
Oxidative stress;
R2*;
Striatum;
Susceptibility weighted imaging;
AGE-RELATED DIFFERENCES;
DEEP GRAY-MATTER;
BRAIN IRON;
IN-VIVO;
BASAL GANGLIA;
CEREBRAL MICROBLEEDS;
OXIDATIVE STRESS;
DEPOSITION;
MITOCHONDRIA;
INFLAMMATION;
D O I:
10.1016/j.neuroimage.2015.12.045
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
Accumulation of non-heme iron is believed to play a major role in neurodegeneration of the basal ganglia. In healthy aging, however, the temporal relationship between change in brain iron content and age-related volume loss is unclear. Here, we present the first long-term longitudinal multi-occasion investigation of changes in iron content and volume in the neostriatum in a sample of healthy middle-aged and older adults (N = 32; ages 49-83 years at baseline). Iron content, estimated via R2* relaxometry, increased in the putamen, but not the caudate nucleus. In the former, the rate of accumulation was coupled with change in volume. Moreover, greater baseline iron content predicted faster shrinkage and smaller volumes seven years later. Older age partially accounted for individual differences in neostriatal iron content and volume, but vascular risk did not. Thus, brain iron content may be a promising biomarker of impending decline in normal aging. (C) 2015 Elsevier Inc. All rights reserved.
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页码:11 / 20
页数:10
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