Redox-active benzimidazolium sulfonamides as cationic thiolating reagents for reductive cross-coupling of organic halides

被引：24

作者：

Zhang, Weigang ^{[1
]}

Huang, Mengjun ^{[1
]}

Zou, Zhenlei ^{[1
]}

Wu, Zhengguang ^{[1
]}

Ni, Shengyang ^{[1
]}

Kong, Lingyu ^{[1
]}

Zheng, Youxuan ^{[1
]}

Wang, Yi ^{[1
]}

Pan, Yi ^{[1
]}

机构：

[1] Nanjing Univ, Collaborat Innovat Ctr Adv Microstruct, Sch Chem & Chem Engn, State Key Lab Coordinat Chem,Jiangsu Key Lab Ad, Nanjing 210023, Peoples R China

来源：

CHEMICAL SCIENCE | 2021年 / 12卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Amides - Redox reactions - Sulfur compounds - Chemical bonds;

D O I：

10.1039/d0sc06446g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Redox-active benzimidazolium sulfonamides as thiolating reagents have been developed for reductive C-S bond coupling. The IMDN-SO2R reagent provides a bench-stable cationic precursor to generate a portfolio of highly active N-S intermediates, which can be successfully applied in cross-electrophilic coupling with various organic halides. The employment of an electrophilic sulfur source solved the problem of catalyst deactivation and avoided odorous thiols, featuring practical conditions, broad substrate scope, and excellent tolerance.

引用

页码：2509 / 2514

页数：6