Alcohol conditioned contexts enhance positive subjective alcohol effects and consumption

被引:5
作者
Lutz, Joseph A. [1 ]
Childs, Emma [1 ,2 ]
机构
[1] Univ Illinois, Dept Psychiat, 1601 W Taylor St MC912, Chicago, IL 60612 USA
[2] Univ Chicago, Dept Psychiat & Behav Neurosci, 5841 S Maryland Ave, Chicago, IL 60637 USA
基金
美国国家卫生研究院;
关键词
Alcohol; Conditioned place preference; Context; Cues; Human; Self-Administration; CUE-REACTIVITY; ENVIRONMENTAL CONTEXT; OUTCOME EXPECTANCIES; SEEKING BEHAVIOR; PLACE PREFERENCE; DRUG-SEEKING; ETHANOL; RELAPSE; SELF; TOLERANCE;
D O I
10.1016/j.beproc.2021.104340
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Associations between alcohol and the places it is consumed are important at all stages of alcohol abuse and addiction. However, it is not clear how the associations are formed in humans or how they influence drinking, and there are few effective strategies to prevent their pathological effects on alcohol use. We used a human laboratory model to study the effects of alcohol environments on alcohol consumption. Healthy regular binge drinkers completed conditioned place preference (CPP) with 0 vs. 80 mg/100 mL alcohol (Paired Group). Control participants (Unpaired Group) completed sessions without explicit alcohol-room pairings. After conditioning, participants completed alcohol self-administration in either the alcohol- or no alcohol-paired room. Paired group participants reported greater subjective stimulation and euphoria, and consumed more alcohol in the alcoholpaired room in comparison to the no alcohol-paired room, and controls tested in either room. Moreover, the strength of conditioning significantly predicted drinking; participants who exhibited the strongest CPP consumed the most alcohol in the alcohol-paired room. This is the first empirical evidence that laboratory-conditioned alcohol environments directly influence drinking. The results also confirm the viability of the model to examine the mechanisms by which alcohol environments stimulate drinking and to test strategies to counteract their influence on behavior.
引用
收藏
页数:11
相关论文
共 95 条
  • [1] Altman D.G., 1991, Practical statistics for medical research
  • [2] Anton RF, 1999, ALCOHOL RES HEALTH, V23, P165
  • [3] Ethanol-induced conditioned place preference is expressed through a ventral tegmental area dependent mechanism
    Bechtholt, AJ
    Cunningham, CL
    [J]. BEHAVIORAL NEUROSCIENCE, 2005, 119 (01) : 213 - 223
  • [4] Craving, cortisol and behavioral alcohol motivation responses to stress and alcohol cue contexts and discrete cues in binge and non-binge drinkers
    Blaine, Sara K.
    Nautiyal, Nisheet
    Hart, Rachel
    Guarnaccia, J. B.
    Sinha, Rajita
    [J]. ADDICTION BIOLOGY, 2019, 24 (05) : 1096 - 1108
  • [5] Context-dependent sensitization to ethanol in zebrafish (Danio rerio)
    Blaser, Rachel E.
    Koid, Audrey
    Poliner, Rebecca M.
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2010, 95 (03) : 278 - 284
  • [6] CONTEXTUAL CONTROL OF THE EXTINCTION OF CONDITIONED FEAR - TESTS FOR THE ASSOCIATIVE VALUE OF THE CONTEXT
    BOUTON, ME
    KING, DA
    [J]. JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIOR PROCESSES, 1983, 9 (03): : 248 - 265
  • [7] EXPECTATIONS OF REINFORCEMENT FROM ALCOHOL - THEIR DOMAIN AND RELATION TO DRINKING PATTERNS
    BROWN, SA
    GOLDMAN, MS
    INN, A
    ANDERSON, LR
    [J]. JOURNAL OF CONSULTING AND CLINICAL PSYCHOLOGY, 1980, 48 (04) : 419 - 426
  • [8] Context-induced relapse of conditioned behavioral responding to ethanol cues in rats
    Chaudhri, Nadia
    Sahuque, Lacey L.
    Janak, Patricia H.
    [J]. BIOLOGICAL PSYCHIATRY, 2008, 64 (03) : 203 - 210
  • [9] Ethanol seeking triggered by environmental context is attenuated by blocking dopamine D1 receptors in the nucleus accumbens core and shell in rats
    Chaudhri, Nadia
    Sahuque, Lacey L.
    Janak, Patricia H.
    [J]. PSYCHOPHARMACOLOGY, 2009, 207 (02) : 303 - 314
  • [10] Reinstated ethanol-seeking in rats is modulated by environmental context and requires the nucleus accumbens core
    Chaudhri, Nadia
    Sahuque, Lacey L.
    Cone, Jackson J.
    Janak, Patricia H.
    [J]. EUROPEAN JOURNAL OF NEUROSCIENCE, 2008, 28 (11) : 2288 - 2298