Total synthesis of (-)-amphidinolide E

被引：71

作者：

Kim, Chan Hyuk ^{[1
]}

An, Hyo Jung ^{[1
]}

Shin, Won Kyo ^{[1
]}

Yu, Wei ^{[1
]}

Woo, Sang Kook ^{[1
]}

Jung, Soon Kyu ^{[1
]}

Lee, Eun ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Nat Sci, Dept Chem, Seoul 151747, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2006年 / 45卷 / 47期

关键词：

anticancer agents; macrolides; marine natural products; radical cyclization; total synthesis;

D O I：

10.1002/anie.200603363

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The unique structural features of the cytotoxic marine macrolide (-)-amphidinolide E make it an intriguing synthetic target. Its total synthesis has now been completed by employing a radical cyclization of a β-alkoxy acrylate to form the oxolane ring, a Kocienski-Julia olefination to create the E C=C bond, and a lactonization reaction to close the macrocyclic ring. (Chemical Equation Presented). © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：8019 / 8021

页数：3

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