Synthesis and antioxidant activity of 2-methylthio-pyrido[3,2-e][1,2,4] triazolo[1,5-a]pyrimidines

被引：13
作者：
Abuelizz, Hatem A. [1 ]
Taie, Hanan A. A. [2 ]
Marzouk, Mohamed [3 ]
Al-Salahi, Rashad [1 ]
机构：
[1] King Saud Univ, Coll Pharm, Dept Pharmaceut Chem, POB 2457, Riyadh 11451, Saudi Arabia
[2] Natl Res Ctr, Dept Plant Biochem, Div Agr & Biol Res, 33 El Bohouth St, Giza 12622, Egypt
[3] Natl Res Ctr, Ctr Excellence Adv Sci, Chem Nat Prod Grp, 33 El Bohouth St, Cairo 12622, Egypt
来源：
OPEN CHEMISTRY | 2019年 / 17卷 / 01期
关键词：
pyrido-triazolopyrimidines; alkylation; thionation; antioxidants; DPPH; ANTIMICROBIAL ACTIVITY; DERIVATIVES;
D O I：
10.1515/chem-2019-0092
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A series of 2-methylthio-pyrido-triazolopyrimidines (1-17) were prepared by the reaction of dimethyl-N-cyanoimidodithiocarbonate with hydrazinopyridine carboxylic acid as starting reactants. Their chemical structures were affirmed with HREI-MS, IR and NMR analyses. The target compounds (1-17) were evaluated for their antioxidant activity using 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging, ferric reduction antioxidant power (FRAP) and reducing power capability (RPC). The results revealed that some pyrido-triazolopyrimidines showed good activity as antioxidant agents, in particular, compounds 12 and 15 were found to possess good antioxidant activity. Butylated hydroxyl toluene (BHT) was used as reference drug.
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页码：823 / 830
页数：8
相关论文
共 16 条
[1]   In vitro evaluation of new 2-phenoxy-benzo [g][1,2,4]triazolo[1,5-a] quinazoline derivatives as antimicrobial agents [J].
Abuelizz, Hatem A. ;
El-Dib, Rabab A. ;
Marzouk, Mohamed ;
Al-Salahi, Rashad .
MICROBIAL PATHOGENESIS, 2018, 117 :60-67
[2]   Synthesis and Antitumor Activity of 1,2,4-Triazolo[1,5-a]quinazolines [J].
Al-Salahi, R. ;
Marzouk, M. ;
Ashour, A. E. ;
Alswaidan, I. .
ASIAN JOURNAL OF CHEMISTRY, 2014, 26 (07) :2173-2176
[3]   Synthesis of novel 2-phenoxybenzo[g][1,2,4]triazolo[1,5-a]quinazoline and its derivatives starting with diphenyl-N-cyanoimidocarbonate [J].
Al-Salahi, R. A. ;
Marzouk, M. S. .
RUSSIAN JOURNAL OF GENERAL CHEMISTRY, 2016, 86 (07) :1741-1746
[4]   Screening and evaluation of antioxidant activity of some 1,2,4-triazolo[1,5-a] quinazoline derivatives [J].
Al-Salahi, Rashad ;
Anouar, El-Hassane ;
Marzouk, Mohamed ;
Taie, Hanan A. A. ;
Abuelizz, Hatem A. .
FUTURE MEDICINAL CHEMISTRY, 2018, 10 (04) :379-390
[5]   Biological effects of a new set 1,2,4-triazolo[1,5-a]quinazolines on heart rate and blood pressure [J].
Al-Salahi, Rashad ;
El-Tahir, Kamal-Eldin ;
Alswaidan, Ibrahim ;
Lolak, Nabih ;
Hamidaddin, Mohammed ;
Marzouk, Mohamed .
CHEMISTRY CENTRAL JOURNAL, 2014, 8
[6]   Antimicrobial activity of newly synthesized methylsulfanyl-triazoloquinazoline derivatives [J].
Al-Salahi, Rashad ;
Marzouk, Mohamed ;
Awad, Ghada ;
Al-Omar, Mohamed ;
Ezzeldin, Essam .
JOURNAL OF PHARMACY AND PHARMACOLOGY, 2013, 65 (06) :790-797
[7]   A New Series of 2-Alkoxy(aralkoxy)-[1,2,4]triazolo[1,5-a]quinazolin-5-ones as Adenosine Receptor Antagonists [J].
Al-Salahi, Rashad ;
Geffken, Detlef ;
Koellner, Maria .
CHEMICAL & PHARMACEUTICAL BULLETIN, 2011, 59 (06) :730-733
[8]   Synthesis of Novel 2-(Methylthio)benzo[g][1,2,4]triazolo[1,5-a]quinazolin-5-(4H)- one and its Derivatives [J].
Al-Salahi, Rashad A. ;
Marzouk, Mohamed S. ;
Ghabbour, Hazem A. ;
Kun, Fun H. .
LETTERS IN ORGANIC CHEMISTRY, 2014, 11 (10) :759-767
[9]   Antiviral activities of some synthesized methylsulfanyltriazoloquinazoline derivatives [J].
Al-Salahi, Rashad A. ;
Al-Omar, Mohamed A. ;
Alswaidan, Ibrahim ;
Marzouk, Mohamed ;
El-Senousy, Waled M. ;
Amr, Abd El-Galil E. .
RESEARCH ON CHEMICAL INTERMEDIATES, 2015, 41 (01) :151-161
[10]  
Al-Salahi RA, 2013, J PURE APPL MICROBIO, V7, P189
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