Histone methyltransferases, diet nutrients and tumour suppressors

It is well known that an insufficiency of dietary methyl-group donors can cause cancer, and that a deficiency in methylation is characteristic of cancer, but how carcinogenesis results from abnormal methyl-donor metabolism has long remained a matter of speculation. Recently, however, it has been found that some histone methyltransferases, which require methyl donors for activity, are tumour suppressors.