Efficacy of 10% silver nitrate solution in the treatment of common warts: a placebo-controlled, randomized, clinical trial

Background Warts are a common skin lesion, especially in children and young adults, caused by human papillomaviruses. So far, there is no definitive therapy for warts and the treatment is modified regularly to obtain the best result with the least discomfort to the patient. The aim of this placebo-controlled clinical trial was to evaluate the clinical efficacy, tolerability, and safety of 10% silver nitrate solution for the treatment of common warts. Methods Sixty individuals attending pediatrics and dermatology clinics and health centers in Yasuj, south-west of Iran, were recruited. The patients were divided into two groups: 30 patients received 10% silver nitrate solution (case group) and 30 control patients received black ink (placebo group). Silver nitrate solution was used every other day for 3 weeks. After 3 weeks, the patients were evaluated for healing, and treatment was continued for another 3 weeks if the lesions were still present. Results Complete regression of lesions was achieved in 19 of the 30 (63.33%) case patients. No significant side-effect was noted in the treated patients apart from temporary brownish discoloration of the skin which resolved 1 week after treatment. Conclusion This study demonstrated that 10% silver nitrate solution can be used effectively for the treatment of warts with no serious complications.