Disparity in the In Vitro versus In Vivo Regulation of Fibronectin-Binding Proteins by 2 Global Regulators, saeRS and sigB, in Staphylococcus aureus

被引：6

作者：

Cheung, Ambrose L. ^{[1
]}

Yang, Soo-Jin ^{[2
]}

Bayer, Arnold S. ^{[2
,3
]}

Xiong, Yan Q. ^{[2
,3
]}

机构：

[1] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Dept Microbiol, Hanover, NH 03756 USA

[2] Univ Calif Los Angeles, Med Ctr, Los Angeles Biomed Res Inst, Div Infect Dis, Torrance, CA 90502 USA

[3] Univ Calif Los Angeles, David Geffen Sch Med, Torrance, CA 90502 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2009年 / 200卷 / 09期

基金：

美国国家卫生研究院;

关键词：

EXPERIMENTAL INFECTIVE ENDOCARDITIS; GENE-EXPRESSION; AGR; SARA; SIGNALS; OPERON; MODEL;

D O I：

10.1086/606011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Fibronectin-binding protein A plays an important role in Staphylococcus aureus endovascular infections. We characterized the sigB-saeRS-fnbA expression network with fibronectin binding in vitro and in an experimental infective endocarditis (IE) model using parental strains RN6390 and SH1000 and their respective isogenic saeRS mutants. In contrast to the in vitro data, there was no influence of saeRS on fnbA expression in the IE model, yet ex vivo fibronectin binding was reduced in saeRS mutants. Moreover, as opposed to the in vitro findings, sigB appeared to have a positive rather than a negative effect on saeRS expression within cardiac vegetations.

引用

页码：1371 / 1374

页数：4

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