Diffuse Large B-Cell Lymphoma in Chinese Patients Immunophenotypic and Cytogenetic Analyses of 124 Cases

被引：28

作者：

Chen, Yan ^{[1
,2
]}

Han, Tao ^{[3
]}

Iqbal, Javeed ^{[1
]}

Irons, Richard ^{[3
]}

Chan, Wing C. ^{[1
]}

Zhu, Xiongzeng ^{[2
]}

Fu, Kai ^{[1
]}

机构：

[1] Univ Nebraska, Med Ctr, Dept Pathol & Microbiol, Omaha, NE 68198 USA

[2] Shanghai Canc Hosp, Dept Pathol, Shanghai, Peoples R China

[3] Fudan Univ, Fudan Cinpathogen Clin & Mol Res Ctr, Shanghai 200433, Peoples R China

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2010年 / 133卷 / 02期

关键词：

Diffuse large B-cell lymphoma; Immunohistochemical subclassification; Cytogenetic profile; BCL2; expression; China; BCL2; OVEREXPRESSION; EXPRESSION; GENE; TRANSLOCATION; SURVIVAL; SUBSET; PROGNOSIS; PROFILES; SUBTYPE; DEFINES;

D O I：

10.1309/AJCP4H6ADGYDZMOA

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

In diffuse large B-cell lymphoma (DLBCL), BCL2 expression usually correlates with the t(14;18) (q32;q21) in germinal center B-cell (GCB) subtype and with gain/amplification of chromosome 18q21 in the activated B cell-like subtype. Studies have suggested that the GCB subtype is less common in Chinese than in Western populations. We studied 124 Chinese DLBCL cases using immunohistochemical, conventional cytogenetics, and interphase fluorescence it? situ hybridization analyses. A cohort of 114 well-characterized DLBCL cases from Western populations was also analyzed for comparison. Lower incidences of the GCB subtype (P = .0001) and the t(14;18) translocation (P = .0001) were present in Chinese cases. However, BCL2 overexpression was more frequent in Chinese compared with Western cases (P =. 0054). BCL2 expression was associated with gain of chromosome 18/18q in the Chinese and Western cohorts. More interestingly, BCL2 expression was associated with gain of chromosome 3/3q in Chinese DLBCL cases, whereas this association was less significant in Western cases.

引用

页码：305 / 313

页数：9

共 29 条

[1] Primary testicular diffuse large B-cell lymphoma belongs to the nongerminal center B-cell-like subgroup: a study of 18 cases [J].

Al-Abbadi, Mousa A. ;

Hattab, Eyas M. ;

Tarawneh, Musleh S. ;

Amr, Samir S. ;

Orazi, Attilio ;

Ulbright, Thomas M. .

MODERN PATHOLOGY, 2006, 19 (12) :1521-1527

[2] Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].

Alizadeh, AA ;

Eisen, MB ;

Davis, RE ;

Ma, C ;

Lossos, IS ;

Rosenwald, A ;

Boldrick, JG ;

Sabet, H ;

Tran, T ;

Yu, X ;

Powell, JI ;

Yang, LM ;

Marti, GE ;

Moore, T ;

Hudson, J ;

Lu, LS ;

Lewis, DB ;

Tibshirani, R ;

Sherlock, G ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Warnke, R ;

Levy, R ;

Wilson, W ;

Grever, MR ;

Byrd, JC ;

Botstein, D ;

Brown, PO ;

Staudt, LM .

NATURE, 2000, 403 (6769) :503-511

[3]

Banham AH, 2001, CANCER RES, V61, P8820

[4] Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction [J].

Bea, S ;

Zettl, A ;

Wright, G ;

Salaverria, I ;

Jehn, P ;

Moreno, V ;

Burek, C ;

Ott, G ;

Puig, X ;

Yang, LM ;

Lopez-Guillermo, A ;

Chan, WC ;

Greiner, TC ;

Weisenburger, DD ;

Armitage, JO ;

Gascoyne, RD ;

Connors, JM ;

Grogan, TM ;

Braziel, R ;

Fisher, RI ;

Smeland, EB ;

Kvaloy, S ;

Holte, H ;

Delabie, J ;

Simon, R ;

Powell, J ;

Wilson, WH ;

Jaffe, ES ;

Montserrat, E ;

Muller-Hermelink, HK ;

Staudt, LM ;

Campo, E ;

Rosenwald, A .

BLOOD, 2005, 106 (09) :3183-3190

[5] A uniform activated B-cell-like in-immunophenotype might explain the poor prognosis of primary central nervous system lymphomas:: analysis of 83 cases [J].

Camilleri-Broët, S ;

Crinière, E ;

Broët, P ;

Delwail, V ;

Mokhtari, K ;

Moreau, A ;

Kujas, M ;

Raphaël, M ;

Iraqi, W ;

Sautès-Fridman, C ;

Colombat, P ;

Hoang-Xuan, K ;

Martin, A .

BLOOD, 2006, 107 (01) :190-196

[6]

Chan WC, 1997, BLOOD, V89, P3909

[7] High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6-deregulating mutations, in gastric lymphoma [J].

Chen, Yun-Wen ;

Hu, Xiao-Tong ;

Liang, Anthony C. ;

Au, Wing-Yan ;

So, Chi-Chiu ;

Wong, Michelle L. ;

Shen, Lijun ;

Tao, Qian ;

Chu, Kent-Man ;

Kwong, Yok-Lam ;

Liang, Raymond H. ;

Srivastava, Gopesh .

BLOOD, 2006, 108 (07) :2373-2383

[8] A New Immunostain Algorithm Classifies Diffuse Large B-Cell Lymphoma into Molecular Subtypes with High Accuracy [J].

Choi, William W. L. ;

Weisenburger, Dennis D. ;

Greiner, Timothy C. ;

Piris, Miguel A. ;

Banham, Alison H. ;

Delabie, Jan ;

Braziel, Rita M. ;

Geng, Huimin ;

Iqbal, Javeed ;

Lenz, Georg ;

Vose, Julie M. ;

Hans, Christine P. ;

Fu, Kai ;

Smith, Lynette M. ;

Li, Min ;

Liu, Zhongfeng ;

Gascoyne, Randy D. ;

Rosenwald, Andreas ;

Ott, German ;

Rimsza, Lisa M. ;

Campo, Elias ;

Jaffe, Elaine S. ;

Jaye, David L. ;

Staudt, Louis M. ;

Chan, Wing C. .

CLINICAL CANCER RESEARCH, 2009, 15 (17) :5494-5502

[9] Diffuse large cell lymphoma [J].

Coiffier, B .

CURRENT OPINION IN ONCOLOGY, 2001, 13 (05) :325-334

[10] Constitutive nuclear factor κB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells [J].

Davis, RE ;

Brown, KD ;

Siebenlist, U ;

Staudt, LM .

JOURNAL OF EXPERIMENTAL MEDICINE, 2001, 194 (12) :1861-1874

← 1 2 3 →